Uxbridge was created by the Redistribution of Seats Act in 1885. Its first MP was the antiquary and genealogist Frederick Dixon-Hartland, a Conservative, whose book A Genealogical and Chronological Chart of the Royal and Distinguished Houses of Europe (1854) was followed by a survey of the tombs of the same royal families.
At the 1910 election, Charles Thomas Mills retained the seat for the Tories, aged only 23, making him the baby of the House. At the outbreak of war, he switched regiments so he could be posted to the front more quickly. He served with the Scots Guards and was killed by shrapnel at the battle of Loos on 6 October 1915.