How and why do we use animals in research?

There are few topics as emotive as the use of animals in research, and few topics where public trust is so essential. This is your chance to have your say.

At a meeting recently, one of our clinical scientists described how she had given a talk to prospective medical students about her research. They expressed surprise that medical research involved the use of animals. How, she wondered, did they think new drugs were developed?

There is a lot of misunderstanding and, for want of a better word, ignorance, about how and why animals are used in research. At a series of recent focus groups, for example, participants believed that cosmetics were still tested on animals. In fact, this practice has not been allowed in the UK since 1998 and was outlawed across Europe in 2009, and from this year no cosmetics tested on animals can be sold in the EU, regardless of where the testing took place. 

It is misconceptions such as these that drive home the need for scientists to talk about their work and which partly underlie the Concordat on Openness on Animal Research being developed by Understanding Animal Research (UAR).

Animals are essential for improving our understanding of health and disease, from how mental illness arises from the circuitry in the brain, to improving surgical procedures and developing new medicines to keep us – and our pets and livestock – healthy. We are constantly refining our techniques: in many cases, we are able to replace animal use with new technologies. Of course researchers would like to see the day when animals are no longer required for medical research.  Unfortunately we are not there yet.

As a nation of animal lovers, it is understandable that many of us feel uncomfortable with the idea that we deliberately make our animals sick in the name of medical research. This is why we believe that scientists must be open about their work and what it entails so that the public can scrutinise it and hold them to account.

The UK has some of the strictest legislation in the world when it comes to research using animals. Every researcher who wishes to use animals must apply to the Home Office for a licence and must show why animals are required and that the eventual benefits of the research outweigh the harm to the animals involved. In addition, the Wellcome Trust, like all other major funders of research, insists that researchers demonstrate a commitment to the "3Rs" – the reduction, refinement and replacement of the use of animals in research.

We thought the research community was doing a reasonable job of communicating what they do and how they do it, but towards the end of last year we received a wake-up call. A survey carried out by Ipsos MORI on behalf of the government showed that the number of people who ‘could accept the use of animals in research’ had fallen – not by a huge amount, but a decline in support nevertheless.

Ironically, one reason for this decline may be the safer environment in which scientists now conduct their research. A decade ago, animal rights activists waged a campaign of intimidation towards animal researchers, with threats of physical violence, attacks on labs and even bombs. A small, but courageous, cohort of scientists stood up to them publicly, explaining their work and why it was important. Now, thanks to measures aimed at tackling extremism, such attacks are a thing of the past, but this has meant that scientists are no longer called on as often to explain why using animals is necessary for scientific and medical progress.

When the results of the survey were released, a group of funders, charities, learned societies, universities and pharmaceutical companies united to sign a "declaration of openness", committing to becoming more open about the use of animals. This declaration was only intended to be the start of the process, however; we also committed to developing a ‘concordat’ that would detail the measures that we would take to be more open.

Over the past year, UAR has been leading discussions to pull together this concordat. They have sought input from organisations that carry out or fund research using animals, and organisations that are concerned with animal welfare.

The final version of the concordat is due to be launched in spring next year, but today UAR is launching a public consultation to find out what people think about the proposals and what "openness" around the use of animals in research means to them.

Much is made in the scientific world about "public dialogue" and "public engagement" – the need not to talk at the public, but rather to talk and, crucially, listen, to them. There are few topics as emotive as the use of animals in research, and few topics where public trust is so essential. It would be very easy for the research community to assume it knows what people want to know. This is your chance to tell us what you really want to know.

To take part in the public consultation, please visit www.understandinganimalresearch.org.uk.

Nancy Lee is a Senior Policy Advisor at the Wellcome Trust

A labatory technician holds a lab mouse. Photo: Getty
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Under pressure at home, Donald Trump will struggle to deliver what Saudi Arabia wants

Above all, the Gulf states want stability. Can this beleaguered US president bring order?

There is a nervous energy around Riyadh. Fresh palm trees line the roads from the airport, punctuated by a wall of American flags and corporate slogans: “Together we prevail.” All the street lights are suddenly working.

The visit of any American president is always a lavish affair in Saudi Arabia, but there is an optimism to this visit that evaded the Obama years and even the recent visits of Theresa May and Angela Merkel.

Yet, there are two distinct parts to this trip – Trump’s first overseas engagement as president – that will determine its success. The first is relatively straightforward. Trump will sign huge defence contracts worth billions of dollars and offer trading opportunities that allow him to maintain his narrative of economic renewal for American businesses.

For the Saudis, too, these deals will fit into their ambitious project – known as Vision 2030 – to expand and diversify their economy away from its current dependence on oil revenues. Both parties are comfortable with this type of corporate and transactional government, enjoying the gaudy pomp and ceremony that comes with the signing of newly minted deals.

The more complicated aspects of the trip relate to its political dimensions. As the Middle East continues to convulse under the most significant turmoil to envelope it since the collapse of the Ottoman Empire, what Gulf leaders desperately want is the re-establishment of order. At its core, that is what will define Donald Trump’s visit to Saudi Arabia – and the Saudis are optimistic.

Their buoyancy is borne of shared regional interests, not least curbing Iranian influence. Ever since the Arab uprisings in 2011, Tehran has asserted itself across the Levant by organising hundreds of proxies to fight on its behalf in Syria and Iraq. Closer to home, too, the Gulf states accuse Iran of fomenting unrest within Shia communities in Saudi Arabia’s eastern provinces, in Bahrain, and in Yemen.

All of this has left the House of Saud feeling especially vulnerable. Having enjoyed an American security umbrella since the 1970s, Obama’s pursuit of the Iran deal left them feeling particularly exposed.

In part at least, this explains some of the Kingdom’s more frantic actions at home and abroad – including the execution of prominent Shia cleric, Sheikh Nimr al-Nimr, and the war in Yemen. Both are really about posturing to Iran: projecting power and demonstrating Saudi resolve.

Trump shares these concerns over Iranian influence, is prepared to look the other way on Saudi Arabia’s war in Yemen, and is deeply opposed to Obama’s nuclear deal. Riyadh believes he will restore the status quo and is encouraged by the direction of travel.

Just last month Trump commissioned a review of the Iran deal while the US Treasury imposed sanctions on two Iranian officials. Saudi Arabia also welcomed Trump’s decision to launch cruise missiles against a Syrian military base last month after Bashar al-Assad used chemical weapons in the town of Khan Sheikhoun.

These measures have been largely tokenistic, but their broader impact has been very significant. The Saudis, and their Gulf partners more generally, feel greatly reassured. This is an American presence in the region that is aligned to their interests, that they know well and can manage.

That is why Gulf states have rushed to embrace the new president ever since he first entered the Oval Office. Saudi Arabia’s deputy crown prince, Mohammed bin Salman (colloquially known simply as “MBS”), already visited him in Washington earlier this year. The Emiratis and others followed shortly afterwards.

A spokesman for Mohammed bin Salman later described the meeting with Trump as an “historical turning point” in relations between the two countries. A White House readout of the meeting baldly stated: “The President and the deputy crown prince noted the importance of confronting Iran's destabilising regional activities.”

Now that Trump is visiting them, the Saudis are hoping to broker an even broader series of engagements between the current administration and the Islamic world. To that end, they are bringing 24 different Muslim leaders to Saudi Arabia for this visit.

This is where Trump’s visit is likely to be fraught because he plans to deliver a major speech about Islam during his visit – a move that has seemingly no positives associated with it.

There is a lot of interest (and bemusement) from ordinary Saudis about what Trump will actually say. Most are willing to look beyond his divisive campaign rhetoric – he did, after all, declare “I think Islam hates us” – and listen to him in Riyadh. But what can he say?

Either he will indulge his audience by describing Islam as a great civilisation, thereby angering much of his political base; or he will stick to the deeply hostile rhetoric of his campaign.

There is, of course, room for an informed, careful, and nuanced speech to be made on the topic, but these are not adjectives commonly associated with Donald Trump. Indeed, the pressure is on.

He will be on the road for nine days at a time when pressure is building over the sacking of the former FBI director James Comey and the ongoing investigation into former national security advisor Michael Flynn’s contacts with Russia.

It is already being reported that Trump is not entirely enthusiastic about such a long overseas programme, but he is committed now. As with almost everything concerning his presidency, this extra pressure adds a wild air of unpredictability to what could happen.

Away from the lucrative deals and glad-handing, this will be the real standard by which to measure the success of Trump’s visit. For a relationship principally defined by its pursuit of stability, whether Trump can deliver what the Gulf really wants remains to be seen.

Shiraz Maher is a contributing writer for the New Statesman and a senior research fellow at King’s College London’s International Centre for the Study of Radicalisation.

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