It’s only natural – let’s make it better

If we can improve, we should.

A bad few weeks, then, for misbehaving chromosomes. First, a Hollywood star draws attention to their errant ways. Next, laboratory scientists find a way to cut them out of the picture. And then, just a day later, camera-wielding researchers announce they can spot the miscreants a mile off.

We can only hope that the IVF pioneer Robert Edwards was given a special preview of the latter research before he died last month. IVF has always been criticised for raising too much hope and too much cash. A round can cost a couple £10,000 yet the chance of it ending in a live birth in the UK is still only 26 per cent. Now, however, a relatively straightforward technique of watching for misbehaving chromosomes might rocket that success rate up to 80 per cent.

The technique sidelines the entirely natural shortcomings of our chromosomes – the packages of DNA inside every cell nucleus. Even in normal circumstances, roughly half of all fertilised eggs carry some kind of abnormality. This predisposes the embryo to problems and usually ends the pregnancy before it begins. But in the sealed glass box where an IVF embryo begins, those chromosomal problems expose themselves in a way that allows doctors to choose the one with the best chance of survival.

The four-day process of turning into a blastocyst, the ball of cells that would normally be implanted in the mother’s womb, takes about six hours longer if there is a chromosomal problem. Using time-lapse photography, you can see which embryos have issues and which are ideal for implantation. The simplicity of the technique would no doubt have brought a smile to Edwards’s face.

He would have been less happy about this month’s press surrounding the breakthrough in human cloning. Scare stories abounded – the Daily Mail went with the headline “New spectre of cloned babies” – and much was made of how it is the same technique as produced Dolly the Sheep, who died prematurely due to abnormalities induced by the cloning process.

The breakthrough is not aimed at making new human beings, however: the idea is to make ill human beings feel like new. First, take a cell from the patient and fuse it with a human egg cell that has had its genetic information removed. The egg then develops into a source of embryonic stem cells that can be turned into bone, blood, heart or liver tissue, or anything else that might be necessary for the patient’s return to health. Such tissues would not be rejected by the immune system, because they would be a perfect match for the patient’s biology.

Until now, the only hope of doing this has been to use chemicals to turn back the clock on a cell, so that it rewinds to the state where it could become any kind of tissue. This chemical approach, however, creates a high chance of inducing abnormalities that elevate the risk of subsequent problems – cancer, for instance.

Cancer comes naturally, too: it has been our constant companion throughout human history. However, this natural phenomenon also suffered a setback this month. The actress Angelina Jolie announced that she had undergone a double mastectomy to counter an inherited genetic fault (on chromosome 17, but there’s a related fault that can appear on chromosome 13) that would almost certainly give her breast cancer. There’s a very strong chance the surgery will have saved her from a premature death, and her courageous broadcasting of the news will put many other women on the path to saving themselves. Take that, nature.

A nucleus being injected from a micropipette into an enucleated oocyte. Photograph: Getty Images

Michael Brooks holds a PhD in quantum physics. He writes a weekly science column for the New Statesman, and his most recent book is At the Edge of Uncertainty: 11 Discoveries Taking Science by Surprise.

This article first appeared in the 27 May 2013 issue of the New Statesman, You were the future once

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“Stinking Googles should be killed”: why 4chan is using a search engine as a racist slur

Users of the anonymous forum are targeting Google after the company introduced a programme for censoring abusive language.

Contains examples of racist language and memes.

“You were born a Google, and you are going to die a Google.”

Despite the lack of obscenity and profanity in this sentence, you have probably realised it was intended to be offensive. It is just one of hundreds of similar messages posted by the users of 4chan’s Pol board – an anonymous forum where people go to be politically incorrect. But they haven’t suddenly seen the error of their ways about using the n-word to demean their fellow human beings – instead they are trying to make the word “Google” itself become a racist slur.

In an undertaking known as “Operation Google”, some 4chan users are resisting Google’s latest artificial intelligence program, Conversation AI, by swapping smears for the names of Google products. Conversation AI aims to spot and flag offensive language online, with the eventual possibility that it could automatically delete abusive comments. The famously outspoken forum 4chan, and the similar website 8chan, didn’t like this, and began their campaign which sees them refer to “Jews” as “Skypes”, Muslims as “Skittles”, and black people as “Googles”.

If it weren’t for the utterly abhorrent racism – which includes users conflating Google’s chat tool “Hangouts” with pictures of lynched African-Americans – it would be a genius idea. The group aims to force Google to censor its own name, making its AI redundant. Yet some have acknowledged this might not ultimately work – as the AI will be able to use contextual clues to filter out when “Google” is used positively or pejoratively – and their ultimate aim is now simply to make “Google” a racist slur as revenge.


Posters from 4chan

“If you're posting anything on social media, just casually replace n****rs/blacks with googles. Act as if it's already a thing,” wrote one anonymous user. “Ignore the company, just focus on the word. Casually is the important word here – don't force it. In a month or two, Google will find themselves running a company which is effectively called ‘n****r’. And their entire brand is built on that name, so they can't just change it.”

There is no doubt that Conversation AI is questionable to anyone who values free speech. Although most people desire a nicer internet, it is hard to agree that this should be achieved by blocking out large swathes of people, and putting the power to do so in the hands of one company. Additionally, algorithms can’t yet accurately detect sarcasm and humour, so false-positives are highly likely when a bot tries to identify whether something is offensive. Indeed, Wired journalist Andy Greenberg tested Conversation AI out and discovered it gave “I shit you not” 98 out of 100 on its personal attack scale.

Yet these 4chan users have made it impossible to agree with their fight against Google by combining it with their racism. Google scores the word “moron” 99 out of 100 on its offensiveness scale. Had protestors decided to replace this – or possibly even more offensive words like “bitch” or “motherfucker” – with “Google”, pretty much everyone would be on board.

Some 4chan users are aware of this – and indeed it is important not to consider the site a unanimous entity. “You're just making yourselves look like idiots and ruining any legitimate effort to actually do this properly,” wrote one user, while some discussed their concerns that “normies” – ie. normal people – would never join in. Other 4chan users are against Operation Google as they see it as self-censorship, or simply just stupid.


Memes from 4chan

But anyone who disregards these efforts as the work of morons (or should that be Bings?) clearly does not understand the power of 4chan. The site brought down Microsoft’s AI Tay in a single day, brought the Unicode swastika (卐) to the top of Google’s trends list in 2008, hacked Sarah Palin’s email account, and leaked a large number of celebrity nudes in 2014. If the Ten Commandments were rewritten for the modern age and Moses took to Mount Sinai to wave two 16GB Tablets in the air, then the number one rule would be short and sweet: Thou shalt not mess with 4chan.

It is unclear yet how Google will respond to the attack, and whether this will ultimately affect the AI. Yet despite what ten years of Disney conditioning taught us as children, the world isn’t split into goodies and baddies. While 4chan’s methods are deplorable, their aim of questioning whether one company should have the power to censor the internet is not.

Google also hit headlines this week for its new “YouTube Heroes” program, a system that sees YouTube users rewarded with points when they flag offensive videos. It’s not hard to see how this kind of crowdsourced censorship is undesirable, particularly again as the chance for things to be incorrectly flagged is huge. A few weeks ago, popular YouTubers also hit back at censorship that saw them lose their advertising money from the site, leading #YouTubeIsOverParty to trend on Twitter. Perhaps ultimately, 4chan didn't need to go on a campaign to damage Google's name. It might already have been doing a good enough job of that itself.

Google has been contacted for comment.

Amelia Tait is a technology and digital culture writer at the New Statesman.