Could melody analysis spot the bum notes in our brain patterns?

Music in the brain.

The culmination of Steven Spielberg's 1977 classic Close Encounters of the Third Kind gave us one of the great moments in sci-fi movie history. It starts with a simple, unforgettable five-note melody – the musical phrase used by US government scientists in an attempt to communicate with a huge UFO that has just descended on the rocky Wyoming countryside. There's a hushed pause as the last note drifts in the night air, followed by a deafening blast as the alien vessel gives its rumbling response. Before we know it, the two parties are bouncing arpeggios off one another; a beautiful, joyful symphonic conversation.

As well as providing a wondrously optimistic antidote to the end-of-days mentality of today's chrome-plated alien blockbusters, that final sequence perfectly articulates the idea of melody as a universal language, one that might be used to explore previously unfathomable mysteries.

In many ways, the human brain is almost as alien to us as the extraterrestrial visitors of Close Encounters. Our relationship with our brains is a little like the relationship most of us have with our PCs – we use them intuitively and we understand the surface processes, but we've only the most basic understanding of how everything works under the hood.

With researchers still struggling to get to grips with the brain's inner workings, the treatment or management of an incredibly varied disorder like epilepsy remains an uphill struggle for medical institutions. One of the keys to better management of epilepsy is the ability to forecast impending seizures, the disorder's main cause of death. Clinical studies in this area predominantly focus on the use of electroencephalogram (EEG) data, which records the brain's electrical activity, but the difficulty involved in accurately interpreting this data is a recurring problem.    

A just-launched European research project, spearheaded by the Italian Association for the Research on Brain and Spinal Cord Diseases (ARCEM), aims to prove that the universal language of melody could provide a solution to this problem. The project has pulled together neuroscientists, IT specialists, musicians and music analysts in an attempt to predict impending seizures using a method called data sonification.

Data sonification is the process of expressing visual data, like EEG read-outs, in the form of melodies. The project is investigating whether tying EEG data sets to musical melodies could help researchers, and eventually doctors, to spot the abnormal brain activity that prefaces a possible seizure.

What advantages does turning EEG data into melody streams bring over the current methods of studying visual brain pattern data to predict epileptic seizures? According to the project team, turning visual data into audio melodies could help researchers to sequence and conceptualise the brain's activity over time, increasing the possibility of catching the hidden signs that could signal a seizure. These signs would be expressed as an abnormal or jarring sound in the melody, essentially turning seizure prediction into a clinical search for a bum note.

Data sonification also brings a more human advantage – our intrinsic ability to spot the off-key note in a melody. The ear is naturally attuned to audio patterns and detecting irregularities within them. The project team believes that expressing EEG data musically could help doctors and researchers identify seizure-indicative anomalies more easily than looking at graphs and read-outs.

Unfortunately, it'll be a while before we find out if this intriguing approach will bear fruit in the field of epileptology. The project has only just begun to gather the huge volumes of EEG data needed to validate the data sonification technique; the team hopes to present some preliminary results by the end of 2013.  

Although it's too early to prove the effectiveness of data sonification for predicting seizures, there's something beautiful about the idea that music, the universal language, might hold the key to furthering our understanding, not of visitors from another planet, but of the inner recesses of our own minds. Spielberg would be proud.

Link to full feature: http://www.hospitalmanagement.net/features/featuretuned-in-tracking-epilepsy-melody-analysis-neurology/

Photograph: Getty Images

 

Chris Lo is a senior technology writer for the NRI Digital network.

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Should London leave the UK?

Almost 60 per cent of Londoners voted to stay in the EU. Is it time for the city to say good by to Brexit Britain and go it alone?

Amid the shocked dismay of Brexit on Friday morning, there was some small, vindictive consolation to be had from the discomfort of Boris Johnson as he left his handsome home in EU-loving Islington to cat-calls from inflamed north London europhiles. They weren’t alone in their displeasure at the result. Soon, a petition calling for “Londependence” had gathered tens of thousands of names and Sadiq Khan, Johnson’s successor as London mayor, was being urged to declare the capital a separate city-state that would defiantly remain in the EU.

Well, he did have a mandate of a kind: almost 60 per cent of Londoners thought the UK would be Stronger In. It was the largest Remain margin in England – even larger than the hefty one of 14 per cent by which Khan defeated Tory eurosceptic Zac Goldsmith to become mayor in May – and not much smaller than Scotland’s. Khan’s response was to stress the importance of retaining access to the single market and to describe as “crucial” London having an input into the renegotiation of the UK’s relationship with the EU, alongside Scotland and Northern Ireland.

It’s possible to take a dim view of all this. Why should London have a special say in the terms on which the UK withdraws from the EU when it ended up on the wrong side of the people’s will? Calling for London to formally uncouple from the rest of the UK, even as a joke to cheer gloomy Inners up, might be seen as vindicating small-town Outer resentment of the metropolis and its smug elites. In any case, it isn’t going to happen. No, really. There will be no sovereign Greater London nation with its own passport, flag and wraparound border with Home Counties England any time soon.

Imagine the practicalities. Currency wouldn’t be a problem, as the newborn city-state would convert to the euro in a trice, but there would be immediate secessionist agitation in the five London boroughs of 32 that wanted Out: Cheam would assert its historic links with Surrey; stallholders in Romford market would raise the flag of Essex County Council. Then there is the Queen to think about. Plainly, Buckingham Palace could no longer be the HQ of a foreign head of state, but given the monarch’s age would it be fair to turf her out?

Step away from the fun-filled fantasy though, and see that Brexit has underlined just how dependent the UK is on London’s economic power and the case for that power to be protected and even enhanced. Greater London contains 13 per cent of the UK’s population, yet generates 23 per cent of its economic output. Much of the tax raised in London is spent on the rest of the country – 20 per cent by some calculations – largely because it contains more business and higher earners. The capital has long subsidised the rest the UK, just as the EU has funded attempts to regenerate its poorer regions.

Like it or not, foreign capital and foreign labour have been integral to the burgeoning of the “world city” from which even the most europhobic corners of the island nation benefit in terms of public spending. If Leaver mentality outside the capital was partly about resentment of “rich London”, with its bankers and big businesses – handy targets for Nigel Farage – and fuelled by a fear of an alien internationalism London might symbolise, then it may prove to have been sadly self-defeating.

Ensuring that London maintains the economic resilience it has shown since the mid-Nineties must now be a priority for national government, (once it decides to reappear). Pessimists predict a loss of jobs, disinvestment and a decrease in cultural energy. Some have mooted a special post-Brexit deal for the capital that might suit the interests of EU member states too – London’s economy is, after all, larger than that of Denmark, not to mention larger than that of Scotland, Wales and Northern Ireland combined – though what that might be and how that could happen remain obscure.

There is, though, no real barrier to greater devolution of powers to London other than the political will of central government. Allowing more decisions about how taxes raised in the capital are spent in the capital, both at mayoral and borough level, would strengthen the city in terms of managing its own growth, addressing its (often forgotten) poverty and enhancing the skills of its workforce.

Handing down control over the spending of property taxes, as set out in an influential 2013 report by the London Finance Commission set up by Mayor Johnson, would be a logical place to start. Mayor Khan’s manifesto pledged to campaign for strategic powers over further education and health service co-ordination, so that these can be better tailored to London’s needs. Since Brexit, he has underlined the value of London securing greater command of its own destiny.

This isn’t just a London thing, and neither should it be. Plans are already in place for other English cities and city regions to enjoy more autonomy under the auspices of directly elected “metro mayors”, notably for Greater Manchester and Liverpool and its environs. One of the lessons of Brexit for the UK is that many people have felt that decisions about their futures have been taken at too great a distance from them and with too little regard for what they want and how they feel.

That lesson holds for London too – 40 per cent is a large minority. Boris Johnson was an advocate of devolution to London when he was its mayor and secured some, thanks to the more progressive side of Tory localism. If he becomes prime minister, it would be good for London and for the country as a whole if he remembered that.  

Dave Hill writes the Guardian’s On London column. Find him on Twitter as @DaveHill.