Could melody analysis spot the bum notes in our brain patterns?

Music in the brain.

The culmination of Steven Spielberg's 1977 classic Close Encounters of the Third Kind gave us one of the great moments in sci-fi movie history. It starts with a simple, unforgettable five-note melody – the musical phrase used by US government scientists in an attempt to communicate with a huge UFO that has just descended on the rocky Wyoming countryside. There's a hushed pause as the last note drifts in the night air, followed by a deafening blast as the alien vessel gives its rumbling response. Before we know it, the two parties are bouncing arpeggios off one another; a beautiful, joyful symphonic conversation.

As well as providing a wondrously optimistic antidote to the end-of-days mentality of today's chrome-plated alien blockbusters, that final sequence perfectly articulates the idea of melody as a universal language, one that might be used to explore previously unfathomable mysteries.

In many ways, the human brain is almost as alien to us as the extraterrestrial visitors of Close Encounters. Our relationship with our brains is a little like the relationship most of us have with our PCs – we use them intuitively and we understand the surface processes, but we've only the most basic understanding of how everything works under the hood.

With researchers still struggling to get to grips with the brain's inner workings, the treatment or management of an incredibly varied disorder like epilepsy remains an uphill struggle for medical institutions. One of the keys to better management of epilepsy is the ability to forecast impending seizures, the disorder's main cause of death. Clinical studies in this area predominantly focus on the use of electroencephalogram (EEG) data, which records the brain's electrical activity, but the difficulty involved in accurately interpreting this data is a recurring problem.    

A just-launched European research project, spearheaded by the Italian Association for the Research on Brain and Spinal Cord Diseases (ARCEM), aims to prove that the universal language of melody could provide a solution to this problem. The project has pulled together neuroscientists, IT specialists, musicians and music analysts in an attempt to predict impending seizures using a method called data sonification.

Data sonification is the process of expressing visual data, like EEG read-outs, in the form of melodies. The project is investigating whether tying EEG data sets to musical melodies could help researchers, and eventually doctors, to spot the abnormal brain activity that prefaces a possible seizure.

What advantages does turning EEG data into melody streams bring over the current methods of studying visual brain pattern data to predict epileptic seizures? According to the project team, turning visual data into audio melodies could help researchers to sequence and conceptualise the brain's activity over time, increasing the possibility of catching the hidden signs that could signal a seizure. These signs would be expressed as an abnormal or jarring sound in the melody, essentially turning seizure prediction into a clinical search for a bum note.

Data sonification also brings a more human advantage – our intrinsic ability to spot the off-key note in a melody. The ear is naturally attuned to audio patterns and detecting irregularities within them. The project team believes that expressing EEG data musically could help doctors and researchers identify seizure-indicative anomalies more easily than looking at graphs and read-outs.

Unfortunately, it'll be a while before we find out if this intriguing approach will bear fruit in the field of epileptology. The project has only just begun to gather the huge volumes of EEG data needed to validate the data sonification technique; the team hopes to present some preliminary results by the end of 2013.  

Although it's too early to prove the effectiveness of data sonification for predicting seizures, there's something beautiful about the idea that music, the universal language, might hold the key to furthering our understanding, not of visitors from another planet, but of the inner recesses of our own minds. Spielberg would be proud.

Link to full feature: http://www.hospitalmanagement.net/features/featuretuned-in-tracking-epilepsy-melody-analysis-neurology/

Photograph: Getty Images

 

Chris Lo is a senior technology writer for the NRI Digital network.

Getty
Show Hide image

Leader: The unresolved Eurozone crisis

The continent that once aspired to be a rival superpower to the US is now a byword for decline, and ethnic nationalism and right-wing populism are thriving.

The eurozone crisis was never resolved. It was merely conveniently forgotten. The vote for Brexit, the terrible war in Syria and Donald Trump’s election as US president all distracted from the single currency’s woes. Yet its contradictions endure, a permanent threat to continental European stability and the future cohesion of the European Union.

The resignation of the Italian prime minister Matteo Renzi, following defeat in a constitutional referendum on 4 December, was the moment at which some believed that Europe would be overwhelmed. Among the champions of the No campaign were the anti-euro Five Star Movement (which has led in some recent opinion polls) and the separatist Lega Nord. Opponents of the EU, such as Nigel Farage, hailed the result as a rejection of the single currency.

An Italian exit, if not unthinkable, is far from inevitable, however. The No campaign comprised not only Eurosceptics but pro-Europeans such as the former prime minister Mario Monti and members of Mr Renzi’s liberal-centrist Democratic Party. Few voters treated the referendum as a judgement on the monetary union.

To achieve withdrawal from the euro, the populist Five Star Movement would need first to form a government (no easy task under Italy’s complex multiparty system), then amend the constitution to allow a public vote on Italy’s membership of the currency. Opinion polls continue to show a majority opposed to the return of the lira.

But Europe faces far more immediate dangers. Italy’s fragile banking system has been imperilled by the referendum result and the accompanying fall in investor confidence. In the absence of state aid, the Banca Monte dei Paschi di Siena, the world’s oldest bank, could soon face ruin. Italy’s national debt stands at 132 per cent of GDP, severely limiting its firepower, and its financial sector has amassed $360bn of bad loans. The risk is of a new financial crisis that spreads across the eurozone.

EU leaders’ record to date does not encourage optimism. Seven years after the Greek crisis began, the German government is continuing to advocate the failed path of austerity. On 4 December, Germany’s finance minister, Wolfgang Schäuble, declared that Greece must choose between unpopular “structural reforms” (a euphemism for austerity) or withdrawal from the euro. He insisted that debt relief “would not help” the immiserated country.

Yet the argument that austerity is unsustainable is now heard far beyond the Syriza government. The International Monetary Fund is among those that have demanded “unconditional” debt relief. Under the current bailout terms, Greece’s interest payments on its debt (roughly €330bn) will continually rise, consuming 60 per cent of its budget by 2060. The IMF has rightly proposed an extended repayment period and a fixed interest rate of 1.5 per cent. Faced with German intransigence, it is refusing to provide further funding.

Ever since the European Central Bank president, Mario Draghi, declared in 2012 that he was prepared to do “whatever it takes” to preserve the single currency, EU member states have relied on monetary policy to contain the crisis. This complacent approach could unravel. From the euro’s inception, economists have warned of the dangers of a monetary union that is unmatched by fiscal and political union. The UK, partly for these reasons, wisely rejected membership, but other states have been condemned to stagnation. As Felix Martin writes on page 15, “Italy today is worse off than it was not just in 2007, but in 1997. National output per head has stagnated for 20 years – an astonishing . . . statistic.”

Germany’s refusal to support demand (having benefited from a fixed exchange rate) undermined the principles of European solidarity and shared prosperity. German unemployment has fallen to 4.1 per cent, the lowest level since 1981, but joblessness is at 23.4 per cent in Greece, 19 per cent in Spain and 11.6 per cent in Italy. The youngest have suffered most. Youth unemployment is 46.5 per cent in Greece, 42.6 per cent in Spain and 36.4 per cent in Italy. No social model should tolerate such waste.

“If the euro fails, then Europe fails,” the German chancellor, Angela Merkel, has often asserted. Yet it does not follow that Europe will succeed if the euro survives. The continent that once aspired to be a rival superpower to the US is now a byword for decline, and ethnic nationalism and right-wing populism are thriving. In these circumstances, the surprise has been not voters’ intemperance, but their patience.

This article first appeared in the 08 December 2016 issue of the New Statesman, Brexit to Trump