View all newsletters
Sign up to our newsletters

Support 110 years of independent journalism.

  1. Politics
  2. Health
25 March 2015

Mapping the psychedelic brain: how LSD is making a comeback

Can drugs help depression? Crowdfunding allows science researchers to bypass institutional reservations and study taboo subjects.

By Ian Steadman

More than 40 years after its prohibition by the Misuse of Drugs Act 1971, LSD is making a comeback. Earlier this month came an announcement from Professor David Nutt that the first-ever brain-scanning study into the psychedelic drug had successfully taken place – and that he and his colleagues, Robin Carhart-Harris of Imperial College London and the drugs policy reformer Amanda Feilding of the Beckley Foundation, were seeking to crowd-fund £25,000 from the public in order to process the results. They met their target within 36 hours.

As much as science aims at dispassionate objectivity, there are some areas – recreational drugs being one – in which ignoring the political context is impossible. For example, Nutt is best known for his time as chair of the Advisory Council on the Misuse of Drugs, a role from which he was dismissed by the then home secretary, Alan Johnson, when he argued that the risks of using ecstasy were about the same as riding a horse. Plus, there is institutional disquiet from the bodies that usually fund scientific research when it comes to Class A substances. Crowd-funding is one way to break the cycle. And yet, speaking to Carhart-Harris a few months ago, just as the trial was getting under way, I learned that other studies may be coming soon. There is “a snowball that’s been gaining size” in psychedelics research, he said. “It’s only now that it’s visible to people.”

It turns out that the big, notorious drugs of years past – particularly LSD and psilocybin (the active ingredient in magic mushrooms) but also MDMA (ecstasy) and ketamine – have shown extraordinary promise in the few early trials that have gone ahead. Single, small doses of these drugs appear to alleviate anxiety and depression, even in severe cases, for long periods of time. Researchers in the US and Switzerland performed basic trials in the 1990s but it is only in the past decade that the “stigma” surrounding these drugs has started to fade.

“There’s a generation now where many more [scientists] have personal experience with recreational drugs,” Carhart-Harris says. “That’s one reason why I’m optimistic . . . The potential application of psychedelics to deal with anxiety around dying is substantial.” He tells me that one study of 12 patients found that depression scores were “significantly reduced six months after a single experience”. Post-traumatic stress disorder in veterans could be alleviated by MDMA, while ketamine has proved effective in treating depression – though it is highly toxic.

This most recent study involved giving participants small doses of LSD and scanning them with fMRI and MEG machines to understand which parts of the brain were affected by the drug. “It’s the obvious first question but it’s the biggest, one that’s never been addressed by a modern imaging study,” he adds.

Select and enter your email address Your weekly guide to the best writing on ideas, politics, books and culture every Saturday. The best way to sign up for The Saturday Read is via saturdayread.substack.com The New Statesman's quick and essential guide to the news and politics of the day. The best way to sign up for Morning Call is via morningcall.substack.com Our Thursday ideas newsletter, delving into philosophy, criticism, and intellectual history. The best way to sign up for The Salvo is via thesalvo.substack.com Stay up to date with NS events, subscription offers & updates. Weekly analysis of the shift to a new economy from the New Statesman's Spotlight on Policy team. The best way to sign up for The Green Transition is via spotlightonpolicy.substack.com
  • Administration / Office
  • Arts and Culture
  • Board Member
  • Business / Corporate Services
  • Client / Customer Services
  • Communications
  • Construction, Works, Engineering
  • Education, Curriculum and Teaching
  • Environment, Conservation and NRM
  • Facility / Grounds Management and Maintenance
  • Finance Management
  • Health - Medical and Nursing Management
  • HR, Training and Organisational Development
  • Information and Communications Technology
  • Information Services, Statistics, Records, Archives
  • Infrastructure Management - Transport, Utilities
  • Legal Officers and Practitioners
  • Librarians and Library Management
  • Management
  • Marketing
  • OH&S, Risk Management
  • Operations Management
  • Planning, Policy, Strategy
  • Printing, Design, Publishing, Web
  • Projects, Programs and Advisors
  • Property, Assets and Fleet Management
  • Public Relations and Media
  • Purchasing and Procurement
  • Quality Management
  • Science and Technical Research and Development
  • Security and Law Enforcement
  • Service Delivery
  • Sport and Recreation
  • Travel, Accommodation, Tourism
  • Wellbeing, Community / Social Services
Visit our privacy Policy for more information about our services, how New Statesman Media Group may use, process and share your personal data, including information on your rights in respect of your personal data and how you can unsubscribe from future marketing communications.
THANK YOU

Every drugs study has to be designed to satisfy ethics committees, something that is complicated by the “alarmist” rhetoric that clings to psychedelics. Even more of a challenge is that scientists can’t use any old LSD bought from a dealer – it must be medicinal grade in purity and sterility, which entails paying bespoke pharmaceutical labs to mix up a batch. “Some people quote hundreds of thousands of pounds, close to half a million, for one study [of] 72 people,” Carhart-Harris says. By comparison, getting a licence from the Home Office to work with scheduled drugs is easy.

At the time of writing, the fundraiser is £6,000 off a new £50,000 stretch goal – to explore possible links between LSD and enhanced creativity. Yes, there’s an opportunity for people to volunteer as participants at the next stage.

Content from our partners
The promise of prevention
How Labour hopes to make the UK a leader in green energy
Is now the time to rethink health and care for older people? With Age UK

Select and enter your email address Your weekly guide to the best writing on ideas, politics, books and culture every Saturday. The best way to sign up for The Saturday Read is via saturdayread.substack.com The New Statesman's quick and essential guide to the news and politics of the day. The best way to sign up for Morning Call is via morningcall.substack.com Our Thursday ideas newsletter, delving into philosophy, criticism, and intellectual history. The best way to sign up for The Salvo is via thesalvo.substack.com Stay up to date with NS events, subscription offers & updates. Weekly analysis of the shift to a new economy from the New Statesman's Spotlight on Policy team. The best way to sign up for The Green Transition is via spotlightonpolicy.substack.com
  • Administration / Office
  • Arts and Culture
  • Board Member
  • Business / Corporate Services
  • Client / Customer Services
  • Communications
  • Construction, Works, Engineering
  • Education, Curriculum and Teaching
  • Environment, Conservation and NRM
  • Facility / Grounds Management and Maintenance
  • Finance Management
  • Health - Medical and Nursing Management
  • HR, Training and Organisational Development
  • Information and Communications Technology
  • Information Services, Statistics, Records, Archives
  • Infrastructure Management - Transport, Utilities
  • Legal Officers and Practitioners
  • Librarians and Library Management
  • Management
  • Marketing
  • OH&S, Risk Management
  • Operations Management
  • Planning, Policy, Strategy
  • Printing, Design, Publishing, Web
  • Projects, Programs and Advisors
  • Property, Assets and Fleet Management
  • Public Relations and Media
  • Purchasing and Procurement
  • Quality Management
  • Science and Technical Research and Development
  • Security and Law Enforcement
  • Service Delivery
  • Sport and Recreation
  • Travel, Accommodation, Tourism
  • Wellbeing, Community / Social Services
Visit our privacy Policy for more information about our services, how New Statesman Media Group may use, process and share your personal data, including information on your rights in respect of your personal data and how you can unsubscribe from future marketing communications.
THANK YOU