How and why do we use animals in research?

There are few topics as emotive as the use of animals in research, and few topics where public trust is so essential. This is your chance to have your say.

At a meeting recently, one of our clinical scientists described how she had given a talk to prospective medical students about her research. They expressed surprise that medical research involved the use of animals. How, she wondered, did they think new drugs were developed?

There is a lot of misunderstanding and, for want of a better word, ignorance, about how and why animals are used in research. At a series of recent focus groups, for example, participants believed that cosmetics were still tested on animals. In fact, this practice has not been allowed in the UK since 1998 and was outlawed across Europe in 2009, and from this year no cosmetics tested on animals can be sold in the EU, regardless of where the testing took place. 

It is misconceptions such as these that drive home the need for scientists to talk about their work and which partly underlie the Concordat on Openness on Animal Research being developed by Understanding Animal Research (UAR).

Animals are essential for improving our understanding of health and disease, from how mental illness arises from the circuitry in the brain, to improving surgical procedures and developing new medicines to keep us – and our pets and livestock – healthy. We are constantly refining our techniques: in many cases, we are able to replace animal use with new technologies. Of course researchers would like to see the day when animals are no longer required for medical research.  Unfortunately we are not there yet.

As a nation of animal lovers, it is understandable that many of us feel uncomfortable with the idea that we deliberately make our animals sick in the name of medical research. This is why we believe that scientists must be open about their work and what it entails so that the public can scrutinise it and hold them to account.

The UK has some of the strictest legislation in the world when it comes to research using animals. Every researcher who wishes to use animals must apply to the Home Office for a licence and must show why animals are required and that the eventual benefits of the research outweigh the harm to the animals involved. In addition, the Wellcome Trust, like all other major funders of research, insists that researchers demonstrate a commitment to the "3Rs" – the reduction, refinement and replacement of the use of animals in research.

We thought the research community was doing a reasonable job of communicating what they do and how they do it, but towards the end of last year we received a wake-up call. A survey carried out by Ipsos MORI on behalf of the government showed that the number of people who ‘could accept the use of animals in research’ had fallen – not by a huge amount, but a decline in support nevertheless.

Ironically, one reason for this decline may be the safer environment in which scientists now conduct their research. A decade ago, animal rights activists waged a campaign of intimidation towards animal researchers, with threats of physical violence, attacks on labs and even bombs. A small, but courageous, cohort of scientists stood up to them publicly, explaining their work and why it was important. Now, thanks to measures aimed at tackling extremism, such attacks are a thing of the past, but this has meant that scientists are no longer called on as often to explain why using animals is necessary for scientific and medical progress.

When the results of the survey were released, a group of funders, charities, learned societies, universities and pharmaceutical companies united to sign a "declaration of openness", committing to becoming more open about the use of animals. This declaration was only intended to be the start of the process, however; we also committed to developing a ‘concordat’ that would detail the measures that we would take to be more open.

Over the past year, UAR has been leading discussions to pull together this concordat. They have sought input from organisations that carry out or fund research using animals, and organisations that are concerned with animal welfare.

The final version of the concordat is due to be launched in spring next year, but today UAR is launching a public consultation to find out what people think about the proposals and what "openness" around the use of animals in research means to them.

Much is made in the scientific world about "public dialogue" and "public engagement" – the need not to talk at the public, but rather to talk and, crucially, listen, to them. There are few topics as emotive as the use of animals in research, and few topics where public trust is so essential. It would be very easy for the research community to assume it knows what people want to know. This is your chance to tell us what you really want to know.

To take part in the public consultation, please visit www.understandinganimalresearch.org.uk.

Nancy Lee is a Senior Policy Advisor at the Wellcome Trust

A labatory technician holds a lab mouse. Photo: Getty
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Locals without borders: governments are using diasporas to shape the migration crisis

Governments of countries key to the migration crisis are tapping diaspora influence more than ever before.

Last month, on 21 June, thousands of Eritreans descended on Geneva and marched across the city, finally stopping at the Place des Nations in front of the UN. The demonstrators had come from across Europe: Italy, Germany, London, and a young man who looked blankly at my French and English questions before exclaiming “Svenska!” (“Swedish!”).

They were here to denounce a recent report by the UN Human Rights Council condemning widespread violations of basic rights in Eritrea. According to the protesters, the report was based on shoddy research and is biased and politically-motivated: “Stop regime change agendas!” said one banner.

Two days later, a similarly sized group of Eritreans marched in the same direction, for the opposite reason. This contingent, 10,000-strong according to the organisers, wanted to show their backing for the report, which highlights many of the problems that led them to leave the Horn of Africa in the first place. Forced conscription, extrajudicial killings, and official impunity, all pinpointed by the UN inquiry, have driven a mass exodus to the surrounding region and beyond. In 2015 alone, 47,025 Eritreans crossed the Mediterranean to request asylum in Europe.

Two things stood out. First was the sharp polarisation of the Eritrean diaspora community in Europe, which muddies the waters for outsiders trying to make sense of the situation: how can one side say everything is fine while the other claims massive abuses of rights?

Second was the sheer engagement of this diaspora, some of whom may never have set foot in Eritrea. They had come from across Europe, with or without the help of funding, to stand on a rainy square and fight for the narrative of their nation.

As an Irishman abroad, would I have the commitment to jump on a plane for a political protest with no certain outcome? I probably wouldn’t, but then again my country is not just 25 years old and still struggling to define itself on the international stage.

Individual stakes are also much higher for people like Abraham, an Eritrean in Switzerland who told me how he was forced into the army for seven years before managing to escape via Sudan two years ago. With two children still in Asmara, he has significant skin in the game.

As for the naysayers, they are also under certain pressure. Some reports suggest that the government in Asmara exercises extensive power in certain diaspora circles, threatening to cancel the citizenship of those who denounce the regime or refuse to pay 2 per cent income tax each year.

Ultimately, such a situation can only lead to a committed kind of polarisation where pro-government supporters need to publicly demonstrate their backing, and the anti-government kind have nothing left to lose.

But on a more benign level, the idea of states systematically harnessing the power of the diaspora for domestic gains has also been growing elsewhere – including in Ireland. Historically a nation of emigrants, Ireland has seen its diaspora swell even further following the economic downturn: OECD figures estimate that one in six Irish-born people now live abroad.

In an age of networks and soft power, this represents a sizeable demographic, and a well-educated and well-off one to boot. The government has clearly recognized this. In 2009, the first Global Irish Economic Forum was held to tap into the business know-how of expats, and has since taken place biannually.

More importantly, two years ago the first Minister for the Diaspora was appointed, tasked with taking overall charge of engagement efforts: no longer simply cultural ambassadors operating Irish bars abroad, emigrants are economic and political seeds to be cultivated. A referendum is planned next year on whether to grant them the right to vote from abroad in presidential elections.

Elsewhere, in Germany, the 3m-strong Turkish population has attracted renewed interest from the government of Recep Tayyip Erdogan in recent years. According to a 2014 paper by think tank SWP, Ankara now explicitly designates these Turks abroad as a “diaspora” rather than a scattered group, and adopts clear public diplomacy efforts, channelled through cultural centres, to tap their influence.

This has sometimes rankled in Berlin: although Ankara’s diaspora policy encourages citizens to learn German and integrate into German society, the underlying motivation is one of Turkish self-interest rather than benign assimilation. In a battle for the front-foot, German immigration policy clashes with Turkish emigration policy.

Intra-EU movements, largely unhampered by visa questions, have also become substantial enough to warrant attention. For example, hit hard by the economic downturn and austerity measures, many educated Spaniards and Portuguese have flocked to Northern European cities to seek employment.

London, a melting pot of diasporas from all over the world, is reportedly home to more French people than Bordeaux: together they would make up the sixth largest city in France. As countries continue to rebuild following the financial crisis, forging a connection to the skills and political power of such emigrants is a policy imperative.

And if no other EU country, aside from Ireland, has introduced a dedicated minister for this, the growing economic potentials may spur them to do so.

Diasporas have been around for millennia. Why are governments getting so interested now? And what does it mean for the future of citizenship, nationality, and identity?

Technology is one obvious game-changer. Diasporas not only have more options to keep in touch with their home country, but with so much of daily life now happening on virtual platforms, they also have less reason to integrate in their host society.

It is now almost feasible to ignore the surrounding communities and live quite comfortably in a bubble of media and connections from back home. This then works both ways, with governments increasingly willing to use such communications to maintain links. The “imagined spaces” of nations are morphing into “virtual spaces”, with unpredictable consequences for traditional models of integration.

Marco Funk, a researcher at the EU Institute for Security Studies in Brussels, says that the growing ease of mobility compounds the idea of “people moving from one country to another and staying there” as simply out-of-date.

The coming years, he says, will be marked by patterns of “circular migration”, where citizens hop from one country to another as whim and economic opportunity arise. Governments, especially in an increasingly stagnant Europe, will likely try to beef up links with this mobile generation, especially since it is often pulled from the more educated classes.

Fearing a “brain drain”, yet unable to keep the talent at home, they may foster a more fluid system of “brain exchange”: the diaspora as a mobile resource rather than physical loss.

Of course, none of this will be straightforward, especially at a time when a major fault-line around the world is the future of globalisation and migration. An uptick in nationalist tendencies may mean that diasporas will find themselves (once again) unwilling pawns on a political chessboard, protected or manipulated by governments back home while scapegoated by segments of their host societies.

But one thing is sure: even as walls are rebuilt, diasporas will not disappear, and governments are recognising their power. All politics may remain local, but the local now knows no bounds.