How and why do we use animals in research?

There are few topics as emotive as the use of animals in research, and few topics where public trust is so essential. This is your chance to have your say.

At a meeting recently, one of our clinical scientists described how she had given a talk to prospective medical students about her research. They expressed surprise that medical research involved the use of animals. How, she wondered, did they think new drugs were developed?

There is a lot of misunderstanding and, for want of a better word, ignorance, about how and why animals are used in research. At a series of recent focus groups, for example, participants believed that cosmetics were still tested on animals. In fact, this practice has not been allowed in the UK since 1998 and was outlawed across Europe in 2009, and from this year no cosmetics tested on animals can be sold in the EU, regardless of where the testing took place. 

It is misconceptions such as these that drive home the need for scientists to talk about their work and which partly underlie the Concordat on Openness on Animal Research being developed by Understanding Animal Research (UAR).

Animals are essential for improving our understanding of health and disease, from how mental illness arises from the circuitry in the brain, to improving surgical procedures and developing new medicines to keep us – and our pets and livestock – healthy. We are constantly refining our techniques: in many cases, we are able to replace animal use with new technologies. Of course researchers would like to see the day when animals are no longer required for medical research.  Unfortunately we are not there yet.

As a nation of animal lovers, it is understandable that many of us feel uncomfortable with the idea that we deliberately make our animals sick in the name of medical research. This is why we believe that scientists must be open about their work and what it entails so that the public can scrutinise it and hold them to account.

The UK has some of the strictest legislation in the world when it comes to research using animals. Every researcher who wishes to use animals must apply to the Home Office for a licence and must show why animals are required and that the eventual benefits of the research outweigh the harm to the animals involved. In addition, the Wellcome Trust, like all other major funders of research, insists that researchers demonstrate a commitment to the "3Rs" – the reduction, refinement and replacement of the use of animals in research.

We thought the research community was doing a reasonable job of communicating what they do and how they do it, but towards the end of last year we received a wake-up call. A survey carried out by Ipsos MORI on behalf of the government showed that the number of people who ‘could accept the use of animals in research’ had fallen – not by a huge amount, but a decline in support nevertheless.

Ironically, one reason for this decline may be the safer environment in which scientists now conduct their research. A decade ago, animal rights activists waged a campaign of intimidation towards animal researchers, with threats of physical violence, attacks on labs and even bombs. A small, but courageous, cohort of scientists stood up to them publicly, explaining their work and why it was important. Now, thanks to measures aimed at tackling extremism, such attacks are a thing of the past, but this has meant that scientists are no longer called on as often to explain why using animals is necessary for scientific and medical progress.

When the results of the survey were released, a group of funders, charities, learned societies, universities and pharmaceutical companies united to sign a "declaration of openness", committing to becoming more open about the use of animals. This declaration was only intended to be the start of the process, however; we also committed to developing a ‘concordat’ that would detail the measures that we would take to be more open.

Over the past year, UAR has been leading discussions to pull together this concordat. They have sought input from organisations that carry out or fund research using animals, and organisations that are concerned with animal welfare.

The final version of the concordat is due to be launched in spring next year, but today UAR is launching a public consultation to find out what people think about the proposals and what "openness" around the use of animals in research means to them.

Much is made in the scientific world about "public dialogue" and "public engagement" – the need not to talk at the public, but rather to talk and, crucially, listen, to them. There are few topics as emotive as the use of animals in research, and few topics where public trust is so essential. It would be very easy for the research community to assume it knows what people want to know. This is your chance to tell us what you really want to know.

To take part in the public consultation, please visit www.understandinganimalresearch.org.uk.

Nancy Lee is a Senior Policy Advisor at the Wellcome Trust

A labatory technician holds a lab mouse. Photo: Getty
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What I learnt from the French presidential campaign

A last-minute attack, as many feared, can change everything.

A familiar feeling of tedium was settling in on Thursday night, as my friends and I watched the last TV event before the first round of the French election, held this Sunday. Instead of a neverending debate with the 11 candidates, this time each candidate had ten minutes to defend their policies. All the same, the event was expected to run to four hours and 32 minutes. After hard-left candidate Jean-Luc Mélenchon showed the alarm clock he had brought (because it is “time to wake up”), we were, quite ironically, falling asleep.

But around 9pm, something woke us up. Scanning through tweets, I spotted a news alert: “Shooting on the Champs-Elysées.” A policeman had died. My French friend and I looked at each other. It had started again – the dread, the speculation on social media, the comments from politicians, the inevitable recuperation of yet another (possibly terrorist) attack. That feeling, too, is now a familiar one.

Last night’s events have shaken what was left of a hectic, infuriating campaign marked by scandals, extraordinary uncertainty and growing resentment toward the French political system. The Champs-Elysées shooting happened on the eve of the last day of campaigning. Conservative François Fillon and hard-right Marine Le Pen both decided to cancel their events on Friday to hold press briefings instead. However, this meant they were effectively using the events on the Champs-Elysées as a last mean of getting their message across. We need more security – vote for me.

By contrast, when the news about the shooting filtered into the live TV debate, the centrist Emmanual Macron seemed to try too hard to look presidential, especially compared to Fillon, who channelled his real life prime ministerial experience. 

As my colleague Stephen made clear this morning, it’s Marine Le Pen who benefits from such security scares. But the changed mood could mean it's Fillon, rather than the great liberal hope Macron, who will face her in the run off. It would be only logical to see the big crowds of undecided voters warm to an experienced Conservative with a strong security stance.

If it’s Fillon-Le Pen indeed, then my first lesson learnt on the campaign trail in 2017 will be to never underestimate the voters’ fear – and the candidates’ capacity to play with it. As for lesson number two?

Accusations of rampant corruption will not bury a candidate. Apparently.

Only in March, I was charting Fillon's descent into scandal over multiple accusations of fraud and misuse of public money. It looked like his decision to cling onto his hopes of the Presidency was an egotrip that could ruin his centre-right party. He is polling at 21 per cent, with Mélenchon at 18 and Macron at 23, all within the 2-3 points of margin error acknowledged by pollsters.

Fillon is is now polling at 21 per cent, with Mélenchon at 18  per cent and Macron at 23 per cent, all within the 2-3 points of margin error acknowledged by pollsters. Against Le Pen, all polls suggest Fillon would be victorious – a scenario now ridiculously plausible.

“So it’ll be Fillon-Le Pen, and Fillon will win,” was our conclusion last night. What a humiliation if France elects the candidate being investigated over allegations of misusing half a million euros of public money. He is even said to be ready to “pay the money back” if he is elected – an offer that sounds uncannily like a confession. (“Rends l’argent”, meaning “Pay the money back”, has become a meme used against Fillon on social media and on his campaign trail.)

Old French political parties are dying and must come to terms with rapidly changing times.

Fillon may win, but his party, and the centre-left party of Socialist Benoît Hamon, have lost. The campaign has been fought by independents, from loud “anti-elite” Le Pen and Macron’s personality-cult movement En Marche to Mélenchon’s late but powerful Corbyn-like grassroots movement. Big historical divides of left and right have been rejected by Macron and Le Pen, who both claim to be “neither left nor right.” Even if Fillon, the embodiment of the old politics, wins, he’ll be the last one from the country’s main parties.

Marine will rule France. In the meantime, her agenda will rule everything else.

Le Pen is not playing a short-term game. When her father reached the second round in 2002, I was eight years old. I remember an Italian friend at school saying goodbye to everyone – her parents had planned to move if he won. I grew up seeing his jackass party turning into her nationalist machine. It is hard to see an end to her rule, if only on the ideological front. Le Pen cannot really lose: each campaign she fights is a step closer to the goal and I am now certain nothing can stop her but herself. It will take a Front National presidency to defeat the Front National, for it to go full circle and replace the elite political entities it is now denouncing as out of tune.

There's one last feeling I know I'll come to regard as very familiar - and that's the feeling of grief I'll get seeing Marine Le Pen reaching the second round.

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