How and why do we use animals in research?

There are few topics as emotive as the use of animals in research, and few topics where public trust is so essential. This is your chance to have your say.

At a meeting recently, one of our clinical scientists described how she had given a talk to prospective medical students about her research. They expressed surprise that medical research involved the use of animals. How, she wondered, did they think new drugs were developed?

There is a lot of misunderstanding and, for want of a better word, ignorance, about how and why animals are used in research. At a series of recent focus groups, for example, participants believed that cosmetics were still tested on animals. In fact, this practice has not been allowed in the UK since 1998 and was outlawed across Europe in 2009, and from this year no cosmetics tested on animals can be sold in the EU, regardless of where the testing took place. 

It is misconceptions such as these that drive home the need for scientists to talk about their work and which partly underlie the Concordat on Openness on Animal Research being developed by Understanding Animal Research (UAR).

Animals are essential for improving our understanding of health and disease, from how mental illness arises from the circuitry in the brain, to improving surgical procedures and developing new medicines to keep us – and our pets and livestock – healthy. We are constantly refining our techniques: in many cases, we are able to replace animal use with new technologies. Of course researchers would like to see the day when animals are no longer required for medical research.  Unfortunately we are not there yet.

As a nation of animal lovers, it is understandable that many of us feel uncomfortable with the idea that we deliberately make our animals sick in the name of medical research. This is why we believe that scientists must be open about their work and what it entails so that the public can scrutinise it and hold them to account.

The UK has some of the strictest legislation in the world when it comes to research using animals. Every researcher who wishes to use animals must apply to the Home Office for a licence and must show why animals are required and that the eventual benefits of the research outweigh the harm to the animals involved. In addition, the Wellcome Trust, like all other major funders of research, insists that researchers demonstrate a commitment to the "3Rs" – the reduction, refinement and replacement of the use of animals in research.

We thought the research community was doing a reasonable job of communicating what they do and how they do it, but towards the end of last year we received a wake-up call. A survey carried out by Ipsos MORI on behalf of the government showed that the number of people who ‘could accept the use of animals in research’ had fallen – not by a huge amount, but a decline in support nevertheless.

Ironically, one reason for this decline may be the safer environment in which scientists now conduct their research. A decade ago, animal rights activists waged a campaign of intimidation towards animal researchers, with threats of physical violence, attacks on labs and even bombs. A small, but courageous, cohort of scientists stood up to them publicly, explaining their work and why it was important. Now, thanks to measures aimed at tackling extremism, such attacks are a thing of the past, but this has meant that scientists are no longer called on as often to explain why using animals is necessary for scientific and medical progress.

When the results of the survey were released, a group of funders, charities, learned societies, universities and pharmaceutical companies united to sign a "declaration of openness", committing to becoming more open about the use of animals. This declaration was only intended to be the start of the process, however; we also committed to developing a ‘concordat’ that would detail the measures that we would take to be more open.

Over the past year, UAR has been leading discussions to pull together this concordat. They have sought input from organisations that carry out or fund research using animals, and organisations that are concerned with animal welfare.

The final version of the concordat is due to be launched in spring next year, but today UAR is launching a public consultation to find out what people think about the proposals and what "openness" around the use of animals in research means to them.

Much is made in the scientific world about "public dialogue" and "public engagement" – the need not to talk at the public, but rather to talk and, crucially, listen, to them. There are few topics as emotive as the use of animals in research, and few topics where public trust is so essential. It would be very easy for the research community to assume it knows what people want to know. This is your chance to tell us what you really want to know.

To take part in the public consultation, please visit

Nancy Lee is a Senior Policy Advisor at the Wellcome Trust

A labatory technician holds a lab mouse. Photo: Getty
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In Russia, Stalin is back

New statues and memorabilia are appearing, as Russians overlook the terror to hark back to a perceived era of order and national safety.

It was during the Victory Day march to commemorate those who fought in the World War Two, the Great Patriotic War (as it is known in Russia) that I saw the face of Stalin. A young woman carried a crimson flag with the image of the Leader which appeared amidst the black and white photographs of grandparents remembered on the seventieth anniversary of the victory over the Nazi Germany. Just a few months later I was back in Moscow to face the fact that the fleeting image of Stalin, like a seed dropped into rich soil, has sprouted everywhere. At the busy Moscow Domodedovo airport you can now buy souvenir mugs and badges featuring a man with a moustache, coiffed hair and unsmiling eyes; men wearing Stalin T-shirts walk the streets of Moscow and just in time for the festive season 2016 calendars with the twelve photos of the ”Red Tsar” are spread across the counters of the book shops. Most shockingly, new statues of Stalin have appeared in Lipetsk, Penza and Shelanger, a village in a Russian republic Mari El. The monuments were commissioned and erected by the Russia’s Communist Party. Its leader, Gennadiy Zyuganov, promised new statues to be built in Irkutsk in Siberia and in Donetsk in Eastern Ukraine. Charles de Gaulle, the former French president was right: “Stalin didn't walk away into the past, he dissolved into the future.”

According to a January 2015 survey by an independent, non-profit organisation, founded by a Russian sociologist Yuri Levada, 52 per cent of Russians think that Stalin played a “definitely positive” or ”mostly positive” role in Russia’s history. Stalin’s positive image today is cultivated mostly through his association with the Great Patriotic War. Throughout 2015 the Russian media have been obsessively commemorating the 70th anniversary of the victory over the Nazis, with Stalin, the generalissimo, at its helm. Political psychologist Elena Shestopal, quoted by the Levada Centre, explains that the positive opinion of Stalin is a reflection of the society’s demand for order and national safety. In her view, Russians associate Stalin with the role of the father: strict, demanding and powerful.

Stalin’s resurrection is astounding not least because his role in history and his “personality cult” have been consistently condemned in Russia since 1956. Three years after Stalin’s death, the then General Secretary Khrushchev denounced it at the Communist Party conference. Stalin’s body was removed from the Red Square mausoleum; the monuments commemorating him were taken down and destroyed. During glasnost, the openness period initiated by Gorbachev, some state archives revealing the extent of Stalin’s purges and mass repressions were made public. My own grandfather, Aleksandr Bakunin, who devoted his entire life to the history of the Russia’s Communist Party and its accomplishments, set to work in his seventies to research the newly available materials and write a trilogy about the history of Soviet totalitarianism. In popular literature, Aleksandr Solzhenitsyn made stunning revelations about mass repressions and his personal experiences as a prisoner in a labour camp in his novel The Gulag Archipelago, first openly published in a Russian literary magazine in 1989. In Gorbachev’s days Nikolai Svanidze, a popular Russian TV host, historian and journalist – related to Stalin through his first wife, Ekaterina (Cato) Svanidze – declared that Stalin and Hitler were cut from the same cloth on national television. I do not believe that such a statement would be made by the Russian media today. 

An example of a “Red Tsar” calendar

With knowledge about collectivisation and famine of the 1930s, mass arrests and forced labour, the culture of terror and the totalitarian governance, it is difficult to understand the current sentiment in Russia which makes it acceptable to print Stalin’s image onto T-shirts and mugs. Russians, who approve of Stalin, credit him with turning around the backward agrarian economy with its mostly rural population into an economic and scientific powerhouse, responsible for sending the first man into space. It was allegedly Churchill who said that “Stalin inherited Russia with a wooden plough and left it in possession of atomic weapons”. These sympathisers hail rapid industrialisation and economic progress, forgetting its costs. Mayakovskiy put it well in his poem about the construction of Kuznetsk: “The lips are turning blue from the cold, but the lips recite in unison: ‘In four years this will be a garden city!’”

Stalinists are especially vocal in giving their hero credit for winning the war. By the end of 1930s, the Soviet Union had become the largest economy in Europe and in the 1940s it was the defence industry that carried the Soviet campaign against Hitler. Stalin united people and inspired them to fight the enemy both on the front line and in the factories, according to those who believe in Stalin as “the Leader”. “The European nations are being ungrateful”, they say. “Stalin saved them from the Nazis.” It is inconvenient to remember that it was Stalin who had signed a non-aggression pact with Hitler in August 1939 and had been falsely assured that Germany would not invade the Soviet Union. Stalin disregarded several reports from his own intelligence agents and defected German spies about the advancing of Hitler’s army in 1941. Millions of lives were lost as a result in the first months of the war. As for the gratitude, the Baltic and the eastern European nations are quite right to dispute the post-war reorganisation of Europe, implemented after the Yalta conference, when Stalin, Roosevelt and Churchill agreed to divide their spheres of influence.

After the war, the USSR became the second most powerful nation in the world and a force to be reckoned with in geopolitics, economics and technology. Previously illiterate peasants, Soviet citizens enrolled in universities, became engineers and doctors, went to the theatre and cinema, read and became part of the Soviet miracle. There is a great deal of nostalgia among the older generation in Russia, who mourn the ”golden decades” of the Soviet Union and wish for Russia’s international status to climb again. “We lived better with Stalin than with anyone else who came to power after him. He looked after us. Today only oligarchs live well,” said a Russian woman in her late seventies. One Russian blogger writes that mass repressions were necessary to align the Soviet consciousness to the new ideology, to replace individualism with collective responsibility. He believes that the terror was necessary to maintain order. There is also rising support among the younger generation who see parallels between Putin and Stalin, the two rulers who favour autocracy and ubiquitous state control.

Already in his seventies, my grandfather wrote two books about the genesis and the evolution of the totalitarianism in the Soviet Union. His third book was meant to be about the fall of Stalinism. Despite several heart attacks and a stroke, he continued working. He died from the fatal heart attack, his book unfinished. Perhaps, it was meant to be. Section 86 of the German Criminal Code makes it illegal to display Nazi images and to hail Hitler in Germany. In Russia, Stalin has never been similarly condemned. The Russian government ostensibly does not object to the new statues of Stalin being erected just 60 years after they had been taken down. The nation that has forgotten its own history is terrifying.