How and why do we use animals in research?

There are few topics as emotive as the use of animals in research, and few topics where public trust is so essential. This is your chance to have your say.

At a meeting recently, one of our clinical scientists described how she had given a talk to prospective medical students about her research. They expressed surprise that medical research involved the use of animals. How, she wondered, did they think new drugs were developed?

There is a lot of misunderstanding and, for want of a better word, ignorance, about how and why animals are used in research. At a series of recent focus groups, for example, participants believed that cosmetics were still tested on animals. In fact, this practice has not been allowed in the UK since 1998 and was outlawed across Europe in 2009, and from this year no cosmetics tested on animals can be sold in the EU, regardless of where the testing took place. 

It is misconceptions such as these that drive home the need for scientists to talk about their work and which partly underlie the Concordat on Openness on Animal Research being developed by Understanding Animal Research (UAR).

Animals are essential for improving our understanding of health and disease, from how mental illness arises from the circuitry in the brain, to improving surgical procedures and developing new medicines to keep us – and our pets and livestock – healthy. We are constantly refining our techniques: in many cases, we are able to replace animal use with new technologies. Of course researchers would like to see the day when animals are no longer required for medical research.  Unfortunately we are not there yet.

As a nation of animal lovers, it is understandable that many of us feel uncomfortable with the idea that we deliberately make our animals sick in the name of medical research. This is why we believe that scientists must be open about their work and what it entails so that the public can scrutinise it and hold them to account.

The UK has some of the strictest legislation in the world when it comes to research using animals. Every researcher who wishes to use animals must apply to the Home Office for a licence and must show why animals are required and that the eventual benefits of the research outweigh the harm to the animals involved. In addition, the Wellcome Trust, like all other major funders of research, insists that researchers demonstrate a commitment to the "3Rs" – the reduction, refinement and replacement of the use of animals in research.

We thought the research community was doing a reasonable job of communicating what they do and how they do it, but towards the end of last year we received a wake-up call. A survey carried out by Ipsos MORI on behalf of the government showed that the number of people who ‘could accept the use of animals in research’ had fallen – not by a huge amount, but a decline in support nevertheless.

Ironically, one reason for this decline may be the safer environment in which scientists now conduct their research. A decade ago, animal rights activists waged a campaign of intimidation towards animal researchers, with threats of physical violence, attacks on labs and even bombs. A small, but courageous, cohort of scientists stood up to them publicly, explaining their work and why it was important. Now, thanks to measures aimed at tackling extremism, such attacks are a thing of the past, but this has meant that scientists are no longer called on as often to explain why using animals is necessary for scientific and medical progress.

When the results of the survey were released, a group of funders, charities, learned societies, universities and pharmaceutical companies united to sign a "declaration of openness", committing to becoming more open about the use of animals. This declaration was only intended to be the start of the process, however; we also committed to developing a ‘concordat’ that would detail the measures that we would take to be more open.

Over the past year, UAR has been leading discussions to pull together this concordat. They have sought input from organisations that carry out or fund research using animals, and organisations that are concerned with animal welfare.

The final version of the concordat is due to be launched in spring next year, but today UAR is launching a public consultation to find out what people think about the proposals and what "openness" around the use of animals in research means to them.

Much is made in the scientific world about "public dialogue" and "public engagement" – the need not to talk at the public, but rather to talk and, crucially, listen, to them. There are few topics as emotive as the use of animals in research, and few topics where public trust is so essential. It would be very easy for the research community to assume it knows what people want to know. This is your chance to tell us what you really want to know.

To take part in the public consultation, please visit

Nancy Lee is a Senior Policy Advisor at the Wellcome Trust

A labatory technician holds a lab mouse. Photo: Getty
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America’s domestic terrorists: why there’s no such thing as a “lone wolf”

After the latest attack on Planned Parenthood in Colorado Springs, America must confront the violence escalating at its heart.

First things first: let’s not pretend this is about life.

Three people have died and nine were injured on Friday in the latest attack on a women’s health clinic in the United States. Planned Parenthood in Colorado Springs was besieged by a gunman whose motives remain unclear, but right-to-lifers—who should really be called “forced birth advocates”—have already taken up their keyboards to defend his actions, claiming that women seeking an abortion, or doctors providing them, are never “innocent”. 

This was not unexpected. Abortion providers have been shot and killed before in the United States. The recent book Living in the Crosshairs by David S Cohen and Krysten Connon describes in sanguine detail the extent of domestic terrorism against women’s healthcare facilities, which is increasing as the American right-wing goes into meltdown over women’s continued insistence on having some measure of control over their own damn bodies. As Slate reports

In July, employees at a clinic in the Chicago suburb of Aurora, Illinois, reported an attempted arson. In August, firefighters found half a burning car at the construction site of a future clinic in New Orleans. On Sept. 4, a clinic in Pullman, Washington, was set ablaze at 3:30 a.m., and on Sept. 30, someone broke a window at a Thousand Oaks, California, clinic and threw a makeshift bomb inside.

The real horror here is not just that a forced-birth fanatic attacked a clinic, but that abortion providers across America are obliged to work as if they might, at any time, be attacked by forced-birth fanatics whose right to own a small arsenal of firearms is protected by Congress. 

The United States is bristling with heavily armed right-wingers who believe the law applies to everyone but them. This is the second act of domestic terrorism in America in a week. On Monday, racists shouting the n-word opened fire at a Black Lives Matter protest in Minneapolis, injuring three. This time, the killer is a white man in his 50s. Most American domestic terrorists are white men, which may explain why they are not treated as political agents, and instead dismissed as “lone wolves” and “madmen”.

Terrorism is violence against civilians in the service of ideology. By anyone’s sights, these killers are terrorists, and by the numbers, these terrorists pose substantially more of a threat to American citizens than foreign terrorism—but nobody is calling for background checks on white men, or for members of the republican party to wear ID tags. In America, like many other western nations, people only get to be “terrorists” when they are “outsiders” who go against the political consensus. And there is a significant political consensus behind this bigotry, including within Washington itself. That consensus plays out every time a Republican candidate or Fox news hatebot expresses sorrow for the victims of murder whilst supporting both the motives and the methods of the murderers. If that sounds extreme, let’s remind ourselves that the same politicians who declare that abortion is murder are also telling their constituents that any attempt to prevent them owning and using firearms is an attack on their human rights. 

Take Planned Parenthood. For months now, systematic attempts in Washington to defund the organisation have swamped the nation with anti-choice, anti-woman rhetoric. Donald Trump, the tangerine-tanned tycoon who has managed to become the frontrunner in the republican presidential race not in spite of his swivel-eyed, stage-managed, tub-thumping bigotry but because of it, recently called Planned Parenthood an “abortion factory” and demanded that it be stripped of all state support. Trump, in fact, held a pro-choice position not long ago, but like many US republicans, he is far smarter than he plays. Trump understands that what works for the American public right now, in an absence of real hope, is fanaticism. 

Donald Trump, like many republican candidates, is happy to play the anti-woman, anti-immigrant, racist fanatic in order to pander to white, fundamentalist Christian voters who just want to hear someone tell it like it is. Who just want to hear someone say that all Muslims should be made to wear ID cards, that Black protesters deserve to be “roughed up”, that water-boarding is acceptable even if it doesn’t work because “they deserve it”. Who just want something to believe in, and when the future is a terrifying blank space, the only voice that makes sense anymore is the ugly, violent whisper in the part of your heart that hates humanity, and goddamn but it’s a relief to hear someone speaking that way in a legitimate political forum. Otherwise you might be crazy.

American domestic terrorists are not “lone wolves”. They are entrepreneurial. They may work alone or in small groups, but they are merely the extreme expression of a political system in meltdown. Republican politicians are careful not to alienate voters who might think these shooters had the right idea when they condemn the violence, which they occasionally forget to do right away. In August, a homeless Hispanic man was allegedly beaten to a pulp by two Bostonians, one of whom told the police that he was inspired by Donald Trump’s call for the deportation of “illegals”. Trump responded to the incident by explaining that “people who are following me are very passionate. They love this country and they want this country to be great again.”

But that’s not even the real problem with Donald Trump. The real problem with Donald Trump is that he makes everyone standing just to the left of him look sane. All but one republican governor has declared that refugees from Syria are unwelcome in their states. Across the nation, red states are voting in laws preventing women from accessing abortion, contraception and reproductive healthcare. Earlier this year, as congressmen discussed defunding Planned Parenthood, 300 ‘pro-life’ protesters demonstrated outside the same Colorado clinic where three people died this weekend. On a daily basis, the women who seek treatment at the clinic are apparently forced to face down cohorts of shouting fanatics just to get in the door. To refuse any connection between these daily threats and the gunman who took the violence to its logical extreme is not merely illogical—it is dangerous.

If terrorism is the murder of civilians in the service of a political ideology, the United States is a nation in the grip of a wave of domestic terrorism. It cannot properly be named as such because its logic draws directly from the political consensus of the popular right. If the killers were not white American men, we would be able to call them what they are—and politicians might be obligated to come up with a response beyond “these things happen.”

These things don’t just “happen”. These things happen with escalating, terrifying frequency, and for a reason. The reason is that America is a nation descending into political chaos, unwilling to confront the violent bigotry at its heart, stoked to frenzy by politicians all too willing to feed the violence if it consolidates their own power. It is a political choice, and it demands a political response.

Laurie Penny is a contributing editor to the New Statesman. She is the author of five books, most recently Unspeakable Things.