Four things you should know about the HIV "cure" before you get too excited

The baby might not even have been infected in the first place.

The story everyone is talking about today is the HIV "cure" - the Mississippi baby who, after being blasted with a cocktail of anti-viral drugs at birth, is now, at two years old, apparently virus-free. But when reading the euphoric news stories about it here, here and here, you should bear the following in mind:

1. The baby may not even have been infected in the first place

Here's a weird section in the NYT version of the story. Have a read of the following two paragraphs - are the doctors certain or uncertain that the baby was infected?

“The one uncertainty is really definitive evidence that the child was indeed infected,” said Dr. Daniel R. Kuritzkes, chief of infectious diseases at Brigham and Women’s Hospital in Boston.

Dr. Persaud and some other outside scientists said they were certain the baby — whose name and gender were not disclosed — had been infected. There were five positive tests in the baby’s first month of life — four for viral RNA and one for DNA. And once the treatment started, the virus levels in the baby’s blood declined in the pattern characteristic of infected patients.

The tests are pretty good, but are not usually trusted as a basis for confirmed diagnosis at that early stage. It is normal practice to confirm positive tests at 6 weeks. But as this baby had already been treated by then, lowering its viral load (negative tests came back at 29 days), it would have been difficult to do this. There is a very small chance the baby was not infected.

The virus may not have yet taken a hold on the baby's cells in a permanent way. Here's the WSJ:

Cells in the baby "may have been infected—there was virus around," said Steven Deeks, an AIDS researcher at University of California at San Francisco. "But the cells being infected weren't the type that become long-lived reservoirs."

There is also a small chance the baby was immune to HIV anyway. Around 1 per cent of Caucasians in the US are naturally immune.

Now, these are small chances, but then this baby is an outlier. It was not part of a large study where such anomalies are ruled out. The scientists have said it is unlikely to be replicable. Any way you put it, the baby itself is an anomaly.

2. This "cure" has already been found, and has been used on newly-infected people since 1987. Even if the baby was infected, today's news would simply extend it to newborns.

Today's news applies only to babies. Newborns at that. And it's not really a new method - rather, it's the same idea as PEP: if you have only just been infected, you might avoid HIV if you are immediately given a large amount of anti-HIV drugs. What the scientists confirmed today is that, in terms of emergency treatment, newborns are the same as newly-infected people. 

Here's the NYT again:

“That goes along with the concept that, if you treat before the virus has had an opportunity to establish a large reservoir and before it can destroy the immune system, there’s a chance you can withdraw therapy and have no virus,” said Dr. Anthony S. Fauci, the director of the National Institute for Allergy and Infectious Diseases.

(Oh, and if you were wondering, someone has actually been cured of AIDs before. This was a man called Timothy Brown, a leukemia sufferer who received a bone-marrow transplant from a donor genetically resistant to HIV.)

3. This would not be breaking much ground in preventing HIV in newborns anyway, because we have a solution for that

In countries with access to top-notch medical care (ie western countries), the transference of HIV from mother to child is extremely rare. This is because mothers are treated with antiretroviral therapy during pregnancy - a very effective way of preventing HIV in newborns.

4. Newborns in countries without a solution for that probably wouldn't get this treatment anyway

In countries without access to top-notch medical care, there is no reason that this treatment would be available where antiretroviral pregnancy treatment isn't.

So what does the news mean? Well it means that a few babies in countries with access to this sort of care but whose mothers have somehow slipped through the net of normal practice can be saved. Joyous news. But not quite as joyous as everyone seems to be making out.

UPDATE: This blog originally said that HIV tests at birth couldn't be accurate, but this applies only to antibody tests. The tests on DNA/RNA, which were done in this case, have a greater (although not 100 per cent) degree of accuracy.

HIV cure: not necessarily.. Photograph: Getty Images

Martha Gill writes the weekly Irrational Animals column. You can follow her on Twitter here: @Martha_Gill.

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From Darwin to Damore - the ancient art of using "science" to mask prejudice

Charles Darwin, working at a time when women had little legal rights, declared “woman is a kind of adult child”.

“In addition to the Left’s affinity for those it sees as weak, humans are generally biased towards protecting females,” wrote James Damore, in his now infamous anti-diversity Google memo. “As mentioned before, this likely evolved because males are biologically disposable and because women are generally more co-operative and agreeable than men.” Since the memo was published, hordes of women have come forward to say that views like these – where individuals justify bias on the basis of science – are not uncommon in their traditionally male-dominated fields. Damore’s controversial screed set off discussions about the age old debate: do biological differences justify discrimination?  

Modern science developed in a society which assumed that man was superior over women. Charles Darwin, the father of modern evolutionary biology, who died before women got the right to vote, argued that young children of both genders resembled adult women more than they did adult men; as a result, “woman is a kind of adult child”.

Racial inequality wasn’t immune from this kind of theorising either. As fields such as psychology and genetics developed a greater understanding about the fundamental building blocks of humanity, many prominent researchers such as Francis Galton, Darwin’s cousin, argued that there were biological differences between races which explained the ability of the European race to prosper and gather wealth, while other races fell far behind. The same kind of reasoning fuelled the Nazi eugenics and continues to fuel the alt-right in their many guises today.

Once scorned as blasphemy, today "science" is approached by many non-practitioners with a cult-like reverence. Attributing the differences between races and gender to scientific research carries the allure of empiricism. Opponents of "diversity" would have you believe that scientific research validates racism and sexism, even though one's bleeding heart might wish otherwise. 

The problem is that current scientific research just doesn’t agree. Some branches of science, such as physics, are concerned with irrefutable laws of nature. But the reality, as evidenced by the growing convergence of social sciences like sociology, and life sciences, such as biology, is that science as a whole will, and should change. The research coming out of fields like genetics and psychology paint an increasingly complex picture of humanity. Saying (and proving) that gravity exists isn't factually equivalent to saying, and trying to prove, that women are somehow less capable at their jobs because of presumed inherent traits like submissiveness. 

When it comes to matters of race, the argument against racial realism, as it’s often referred to, is unequivocal. A study in 2002, authored by Neil Risch and others, built on the work of the Human Genome Project to examine the long standing and popular myth of seven distinct races. Researchers found that  “62 per cent of Ethiopians belong to the same cluster as Norwegians, together with 21 per cent of the Afro-Caribbeans, and the ethnic label ‘Asian’ inaccurately describes Chinese and Papuans who were placed almost entirely in separate clusters.” All that means is that white supremacists are wrong, and always have been.

Even the researcher Damore cites in his memo, Bradley Schmitt of Bradley University in Illinois, doesn’t agree with Damore’s conclusions.  Schmitt pointed out, in correspondence with Wired, that biological difference only accounts for about 10 per cent of the variance between men and women in what Damore characterises as female traits, such as neuroticism. In addition, nebulous traits such as being “people-oriented” are difficult to define and have led to wildly contradictory research from people who are experts in the fields. Suggesting that women are bad engineers because they’re neurotic is not only mildly ridiculous, but even unsubstantiated by Damore’s own research.  As many have done before him, Damore couched his own worldview - and what he was trying to convince others of - in the language of rationalism, but ultimately didn't pay attention to the facts.

And, even if you did buy into Damore's memo, a true scientist would retort - so what? It's a fallacy to argue that just because a certain state of affairs prevails, that that is the way that it ought to be. If that was the case, why does humanity march on in the direction of technological and industrial progress?

Humans weren’t meant to travel large distances, or we would possess the ability to do so intrinsically. Boats, cars, airplanes, trains, according to the Damore mindset, would be a perversion of nature. As a species, we consider overcoming biology to be a sign of success. 

Of course, the damage done by these kinds of views is not only that they’re hard to counteract, but that they have real consequences. Throughout history, appeals to the supposed rationalism of scientific research have justified moral atrocities such as ethnic sterilisation, apartheid, the creation of the slave trade, and state-sanctioned genocide.

If those in positions of power genuinely think that black and Hispanic communities are genetically predisposed to crime and murder, they’re very unlikely to invest in education, housing and community centres for those groups. Cycles of poverty then continue, and the myth, dressed up in pseudo-science, is entrenched. 

Damore and those like him will certainly maintain that the evidence for gender differences are on their side. Since he was fired from Google, Damore has become somewhat of an icon to some parts of society, giving interviews to right-wing Youtubers and posing in a dubious shirt parodying the Google logo (it now says Goolag). Never mind that Damore’s beloved science has already proved them wrong.