Your body’s superpowers

The remarkable abilities already inside us.

Norovirus might have laid you low for a short while, but you’re recovering, aren’t you? Your immune system is to die for. Researchers are still getting to grips with how it works but at every turn it has thrown out marvellous surprises. In the early days of vaccination against tuberculosis, for example, it was noted that it protected you not only from TB, but a host of other diseases, too.

We still don’t know why; it’s clear that we have yet to understand the full power of the human immune system. Just in December, for instance, we learned that the system’s T-cells, which fight viruses and bacteria, are not all created equal. Almost all of our knowledge of human T-cells has come from blood samples. But research using T-cells harvested from the organs of New York cadavers has shown that each region of the body has its own particular way of fighting invaders. Columbia University’s Donna Farber, who led the study, believes this discovery may open up the path to tightly focused vaccines that can activate the most appropriate of the body’s immune responses.

Her optimism is supported by another surprise the immune system has just delivered. New Scientist reported this month that there is now hope for a vaccine against age-related macular degeneration (AMD), an incurable condition that blinds millions of people around the world.

AMD comes from the build-up of proteins and other debris on the retina. In healthy people this is cleared away by specialist cells. Those cells stop working in people with AMD. This appears to have two consequences: the build-up of debris continues and the light-sensitive cells of the retina beneath the debris start to die off. The result is a slowly widening black hole at the centre of your field of vision.

Pioneering treatments with a laser can stimulate the nonfunctioning cells to get them going again, which is exactly what Robyn Guymer of the University of Melbourne was trying to do in his trial on 50 patients. The idea was to try the laser treatment in one eye and leave the other eye as a control. Then tests on each eye would show what improvements the procedure could give.

So, you could imagine it was a little frustrating that in the tests the lasered eye didn’t seem to be that much better than the one that had been left alone. But Guymer soon realised this was because the vision of the untreated eye had also improved. The laser surgery had stimulated the patients’ immune system to respond to alarm calls from the eye.

Your eyes are usually offlimits to your immune system. It seems a sensible evolutionary trick, because the immune system’s standard response causes inflammation, which could be catastrophic in an instrument as sensitive as the eye. However, the cells destroyed by the laser appear to send out a signal so loud that the immune system overrides the safety mechanism and sends in the troops – to both eyes – to restore order.

There is now hope that AMD can be treated with a routine procedure at a very early stage, and that those most at risk of developing it can have their immune systems stimulated before the symptoms appear. But there is a wider lesson: with various successes in vaccines against cancer – particularly colon cancer – looking likely in the next few years, it’s becoming clear that the most profitable path for medicine might be to explore partnerships with the remarkable abilities that already lie within us.

Michael Brooks’s “The Secret Anarchy of Science” is published by Profile Books (£8.99)

There is now hope for a vaccine against age-related macular degeneration. Photograph: Getty Images

Michael Brooks holds a PhD in quantum physics. He writes a weekly science column for the New Statesman, and his most recent book is At the Edge of Uncertainty: 11 Discoveries Taking Science by Surprise.

This article first appeared in the 28 January 2013 issue of the New Statesman, After Chavez

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Forget fake news on Facebook – the real filter bubble is you

If people want to receive all their news from a single feed that reinforces their beliefs, there is little that can be done.

It’s Google that vaunts the absurdly optimistic motto “Don’t be evil”, but there are others of Silicon Valley’s techno-nabobs who have equally high-flown moral agendas. Step forward, Mark Zuckerberg of Facebook, who responded this week to the brouhaha surrounding his social media platform’s influence on the US presidential election thus: “We are all blessed to have the ability to make the world better, and we have the responsibility to do it. Let’s go work even harder.”

To which the only possible response – if you’re me – is: “No we aren’t, no we don’t, and I’m going back to my flowery bed to cultivate my garden of inanition.” I mean, where does this guy get off? It’s estimated that a single message from Facebook caused about 340,000 extra voters to pitch up at the polls for the 2010 US congressional elections – while the tech giant actually performed an “experiment”: showing either positive or negative news stories to hundreds of thousands of their members, and so rendering them happier or sadder.

In the past, Facebook employees curating the site’s “trending news” section were apparently told to squash stories that right-wingers might “like”, but in the run-up to the US election the brakes came off and all sorts of fraudulent clickbait was fed to the denizens of the virtual underworld, much – but not all of it – generated by spurious alt-right “news sites”.

Why? Because Facebook doesn’t view itself as a conventional news provider and has no rubric for fact-checking its news content: it can take up to 13 hours for stories about Hillary Clinton eating babies barbecued for her by Barack Obama to be taken down – and in that time Christ knows how many people will have not only given them credence, but also liked or shared them, so passing on the contagion. The result has been something digital analysts describe as a “filter bubble”, a sort of virtual helmet that drops down over your head and ensures that you receive only the sort of news you’re already fit to be imprinted with. Back in the days when everyone read the print edition of the New York Times this sort of manipulation was, it is argued, quite impossible; after all, the US media historically made a fetish of fact-checking, an editorial process that is pretty much unknown in our own press. Why, I’ve published short stories in American magazines and newspapers and had fact-checkers call me up to confirm the veracity of my flights of fancy. No, really.

In psychology, the process by which any given individual colludes in the creation of a personalised “filter bubble” is known as confirmation bias: we’re more inclined to believe the sort of things that validate what we want to believe – and by extension, surely, these are likely to be the sorts of beliefs we want to share with others. It seems to me that the big social media sites, while perhaps blowing up more and bigger filter bubbles, can scarcely be blamed for the confirmation bias. Nor – as yet – have they wreaked the sort of destruction on the world that has burst from the filter bubble known as “Western civilisation” – one that was blown into being by the New York Times, the BBC and all sorts of highly respected media outlets over many decades.

Societies that are both dominant and in the ascendant always imagine their belief systems and the values they enshrine are the best ones. You have only to switch on the radio and hear our politicians blithering on about how they’re going to get both bloodthirsty sides in the Syrian Civil War to behave like pacifist vegetarians in order to see the confirmation bias hard at work.

The Western belief – which has its roots in imperialism, but has bodied forth in the form of liberal humanism – that all is for the best in the world best described by the New York Times’s fact-checkers, is also a sort of filter bubble, haloing almost all of us in its shiny and translucent truth.

Religion? Obviously a good-news feed that many billions of the credulous rely on entirely. Science? Possibly the biggest filter bubble there is in the universe, and one that – if you believe Stephen Hawking – has been inflating since shortly before the Big Bang. After all, any scientific theory is just that: a series of observable (and potentially repeatable) regularities, a bubble of consistency we wander around in, perfectly at ease despite its obvious vulnerability to those little pricks, the unforeseen and the contingent. Let’s face it, what lies behind most people’s beliefs is not facts, but prejudices, and all this carping about algorithms is really the howling of a liberal elite whose own filter bubble has indeed been popped.

A television producer I know once joked that she was considering pitching a reality show to the networks to be called Daily Mail Hate Island. The conceit was that a group of ordinary Britons would be marooned on a desert island where the only news they’d have of the outside world would come in the form of the Daily Mail; viewers would find themselves riveted by watching these benighted folk descend into the barbarism of bigotry as they absorbed ever more factitious twaddle. But as I pointed out to this media innovator, we’re already marooned on Daily Mail Hate Island: it’s called Britain.

If people want to receive all their news from a single feed that constantly and consistently reinforces their beliefs, what are you going to do about it? The current argument is that Facebook’s algorithms reinforce political polarisation, but does anyone really believe better editing on the site will return our troubled present to some prelap­sarian past, let alone carry us forward into a brave new factual future? No, we’re all condemned to collude in the inflation of our own filter bubbles unless we actively seek to challenge every piece of received information, theory, or opinion. And what an exhausting business that would be . . . without the internet.

Will Self is an author and journalist. His books include Umbrella, Shark, The Book of Dave and The Butt. He writes the Madness of Crowds and Real Meals columns for the New Statesman.

This article first appeared in the 24 November 2016 issue of the New Statesman, Blair: out of exile