The study â€“ that points to the critical role of maternal health and well-being during pregnancy - found that young adults whose mothers experienced psychological trauma during their pregnancies show signs of accelerated aging.
Pathik Wadhwa, UCI professor of psychiatry & human behavior, obstetrics & gynecology, pediatrics and epidemiology, said: â€œOur previous research on prenatal stress exposure has shown its effects on long-term metabolic, immune, endocrine and cognitive function. But this is the first to show the impact of prenatal stress on cell aging in humans, and it sheds light on an important biological pathway underlying the developmental origins of adult disease risk.â€
Study participants were healthy 25-year-old women and men born to mothers who had, during pregnancy, experienced psychosocial stress in the form of major, traumatic life events, such as the death or sudden severe illness of an immediate family member.
Blood tests revealed that subjectsâ€™ white blood cells had aged an average of three and a half more years - five among women - than those of individuals whose mothers had uneventful pregnancies.
This hastened aging was evidenced by the shortened length of telomeres, repetitive stretches of DNA-protein complexes that cap and protect the ends of chromosomes.
Telomeres maintain chromosomal stability and control the processes that underlie cellular aging by functioning as a clock that regulates how many times a cell can divide. The shorter the telomere strands, the faster the cell ages.
The telomere maintenance system plays an important role in human disease and longevity, and scientists now know that telomere length is correlated to the risk of disease and premature mortality in humans. Truncated telomeres - such as those found in the white blood cells of study participants - can, for example, be a precursor to diabetes, cancer and coronary heart disease.
â€œThese results indicate that stress exposure in intrauterine life is a significant predictor of adult telomere length - even after accounting for other established prenatal and postnatal influences on telomere length,â€ said Sonja Entringer, UCI assistant professor of pediatrics.
Research indicates that intrauterine conditions play an important role not only in all aspects of fetal development and health across gestation and birth, but also in a wide range of physical and mental health outcomes over an individualâ€™s entire lifespan.
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