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Novartis and the Broad Institute develop a new "cancer encyclopaedia"

Paving the way for a more targeted treatment of cancer patients.

The Swiss pharmaceutical company Novartis and the research firm the Broad Institute have developed a new encyclopaedia cataloguing the genetic and molecular profiles of almost 1,000 human cancer cell lines.

The Cancer Cell Line Encyclopedia will enable researchers around the world to better design clinical trials and further cancer research.

William Sellers, global head of oncology at NIBR, said: “Without access to a systematically collected set of molecular data, researchers can’t match experiments from cell lines with patient tumors when new medicines become available. The Cancer Cell Line Encyclopedia will provide scientists with the ability to build predictive models of what types of patients will respond to a particular class of drugs.”

Each cell line was genetically characterised through a series of high-through-put analyses at the Broad Institute, including global RNA expression patterns, changes in DNA copy number, as well as DNA sequence variations in about 1,600 genes associated with cancer, and pharmacologic profiling for several drugs in about half of the cell lines.

Algorithms were developed to predict drug responses based on the genetic and molecular make-up of cancer cells, according to the lead authors Jordi Barretina and Giordano Caponigro.

Mark Fishman, president of the Novartis Institutes for BioMedical Research (NIBR), said: “Cancer is a genetic disease. Cell lines reflect the genetic disturbances that drive cancers. Probing cell lines with medicines targeted at specific pathways, as done for The Cancer Cell Line Encyclopedia, provides a powerful tool for design of cancer treatment.”

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Why I refuse to complain about email spam

The bleaker things get, the easier it is to be annoyed about absolutely everything.

“I need just one night and your cock
I want to give you a [sic] head Nice [sic] ginger hair and big bubbly boobs”

It reads like poetry. Poetry by an early 00s DVD player that has recently mastered the English language and doesn’t know what to do with it. A DVD player that’s lying on a skip and has a discarded Cornetto sitting atop its plastic exoskeleton like a depressing party hat, sluggishly oozing ice cream into all its crevices. Yes. If a broken and abandoned DVD player were to start writing poems, they’d probably look a bit like that stunningly naïve and post-post-modern cock and bubbly boobs mess.

Innermost contemplations of an obsolete piece of technology or not, these lines of poetry recently appeared in my email junk folder. Subject line: “Sex right now.” Sender: “Teresa Hughes”.

The bleaker things get (economically, politically, socially) the easier it is to complain about absolutely everything. Knowing that I’ll probably spend the rest of my life either living with my parents or renting shitholes from miserly Dickensian landlords makes selfie sticks all the more annoying. And slow walkers. And rugby fans. And people who stand on street corners, shouting about Jesus and doom. All of these things, within the context of generalised rubbishness, are worthy of a billion pissed off tweets.

Spam, on the other hand, the bugbear of the privileged but stressed since about 1996, is one of the increasingly few things about which I refuse to complain. Reason being: spam, the porny kind in particular, has always been there for me… in a way.  

I can’t remember my first email address. Knowing prepubescent me, it was probably a) boringly weird and b) just a fucking abomination. Something like What I can remember though is being emailed about blowjobs way before I knew what they were. Which was, in a sense, educational.

Over the past few days, my junk folder has been inundated by requests from robots who want to do stuff to my penis. This is my first incursion of porn spam in a long while; years, possibly. And I’m finding it almost impossible to be annoyed or disgusted by it. Instead, I’ve been getting nostalgic. Nostalgic for a simpler digital time. A time in which connecting to the internet made a sound like an android with norovirus, and people were trusting enough to click on links in emails with subject lines like, “Mega-PU$$Y 4 U!!!!”.

I like to imagine that, over the next century, great leaders will come and go; empires will rise and fall; bootcut jeans will have moments of fashionableness roughly every fifteen years; and, all the while, people like “Teresa Hughes” will email us reminders that they would dearly like to suck us off, in exchange for a hard drive-melting virus.

Plus, I was only being a little bit facetious about that “poem” thing. When I did an art history elective at uni, a lot of it was spent gazing at pictures of Marcel Duchamp’s “Fountain” (that urinal that’s art) and wondering what art actually is. Can a urinal be art? Can Danny Dyer be art? And, most pressingly, can spam be art? In one word: sure.

Let’s return our attention to those lines of spam at the beginning of the piece. I shall now attempt to apply GCSE-level analysis to Sex Now by “Teresa Hughes” (the lesser-known offspring of Ted and Sylvia, presumably).

The speaker, a woman, in a grab for immediate attention, addresses the reader directly. The line break after “cock” places emphasis on that word, reassuring the reader just how much she “needs” his/her penis. The unusual phrasing in the next line, “a head”, rather than “head”, for example, is a play on words that neatly juxtaposes [seriously, how much did you use the word “juxtapose” in GCSE English essays?] the primal act of giving head with the intellectual act of having one (and using it).  The alliteration in “big bubbly boobs” highlights the exact largeness and roundness pertaining to the speaker’s breasts. Furthermore, she wants us to know that her horniness transcends grammar.

Even furthermore, spam is literature and the world would be a darker place without it. So don’t be a great honking philistine and complain about it.

Eleanor Margolis is a freelance journalist, whose "Lez Miserable" column appears weekly on the New Statesman website.