People inside a model of an intestine in Dresden, Germany. Photo: Getty
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Intelligent stomachs: what if your gut could remember what you had eaten?

Welcome to the world of synthetic biology.

Soon, there will be no denying that it was you who finished the milk. Biological engineers at the Massachusetts Institute of Technology (MIT) have tweaked human gut microbes to work as a biochemical memory system. The bacteria are equipped with the equivalent of a computer’s circuit components to encode a record of what you consume into a bacterium’s DNA.

The research isn’t primarily aiming to deduce who ate what, however. The tweaked bacteria take chemical signals from their environment as an input to create outputs that are an indicator of health. They might turn on a fluorescent protein, say, so that laboratory analysis can detect problems.

Researchers suggest that their primary use will be in identifying (and perhaps even treating) bowel disease and colon cancer. It is likely that programmable bacteria will also find other applications. They are, in effect, an in-stomach sensor that could tell your body anything. “Stop eating this stuff – it’s killing you,” they might say.

The bacterium might simply let you know when you have had enough to eat. Or, if you eat the wrong stuff, it could release chemicals that act as painful stimuli. People with addictions could have bacterial reactions – such as nausea – triggered by the problem substance. The bugs could even be made to produce a pharmaceutical treatment in the body: when they detect a problem, they could feasibly synthesise a chemical solution.

It is unfortunate that the field of synthetic biology has adopted a name with negative connotations. The term “synthetic” can trigger concerns similar to those evoked by “genetic modification”. That’s why UK government funding for synthetic biology is now tied to responsible innovation that proceeds while taking public concerns into account. Though the field is led by US researchers, the UK comes in second, producing about a tenth of the world’s output in papers on synthetic biology.

As with genetic modification, there is little need to panic. Indeed, in some areas, synthetic biology should alleviate public concerns. In a paper published this month, German researchers point out that the tools of synthetic biology can do away with the need for transporting dangerous pathogens around the world – a risky practice. Instead, the pathogen’s genome can be sequenced where it is found and its genetic code emailed to labs for re-creation and analysis in a safe environment.

New advances in synthetic biology are arriving all the time. Last month, researchers at Harvard University unveiled a bacterium with a body clock. E coli doesn’t normally have any kind of circadian rhythm, but when the researchers implanted a protein-based clock mechanism from another organism, the E coli turned a fluorescent protein on and off in a regular, 24-hour cycle. It’s a relatively short step from there to having a gut bacterium that will create and release insulin-regulating drugs or other medicines on a daily schedule.

The new work brings this possibility closer. Although E coli is not a great human companion, the bacterium used in the MIT study is a standard, problem-free inhabitant of the human gut. So, synthetic biology has just got personal. It was only last year that Pamela Silver told Harvard Magazine, “Biological machines and biological computers – all of that should soon become a reality.” This is a field that is progressing rapidly. Steal food while you still can.

Michael Brooks holds a PhD in quantum physics. He writes a weekly science column for the New Statesman, and his most recent book is At the Edge of Uncertainty: 11 Discoveries Taking Science by Surprise.

This article first appeared in the 16 July 2015 issue of the New Statesman, The Motherhood Trap

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No, Jeremy Corbyn did not refuse to condemn the IRA. Please stop saying he did

Guys, seriously.

Okay, I’ll bite. Someone’s gotta say it, so really might as well be me:

No, Jeremy Corbyn did not, this weekend, refuse to condemn the IRA. And no, his choice of words was not just “and all other forms of racism” all over again.

Can’t wait to read my mentions after this one.

Let’s take the two contentions there in order. The claim that Corbyn refused to condem the IRA relates to his appearance on Sky’s Sophy Ridge on Sunday programme yesterday. (For those who haven’t had the pleasure, it’s a weekly political programme, hosted by Sophy Ridge and broadcast on a Sunday. Don’t say I never teach you anything.)

Here’s how Sky’s website reported that interview:


The first paragraph of that story reads:

Labour leader Jeremy Corbyn has been criticised after he refused five times to directly condemn the IRA in an interview with Sky News.

The funny thing is, though, that the third paragraph of that story is this:

He said: “I condemn all the bombing by both the loyalists and the IRA.”

Apparently Jeremy Corbyn has been so widely criticised for refusing to condemn the IRA that people didn’t notice the bit where he specifically said that he condemned the IRA.

Hasn’t he done this before, though? Corbyn’s inability to say he that opposed anti-semitism without appending “and all other forms of racism” was widely – and, to my mind, rightly – criticised. These were weasel words, people argued: an attempt to deflect from a narrow subject where the hard left has often been in the wrong, to a broader one where it wasn’t.

Well, that pissed me off too: an inability to say simply “I oppose anti-semitism” made it look like he did not really think anti-semitism was that big a problem, an impression not relieved by, well, take your pick.

But no, to my mind, this....

“I condemn all the bombing by both the loyalists and the IRA.”, despite its obvious structural similarities, not the same thing.

That’s because the “all other forms of racism thing” is an attempt to distract by bringing in something un-related. It implies that you can’t possibly be soft on anti-semitism if you were tough on Islamophobia or apartheid, and experience shows that simply isn’t true.

But loyalist bombing were not unrelated to IRA ones: they’re very related indeed. There really were atrocities committed on both sides of the Troubles, and while the fatalities were not numerically balanced, neither were they orders of magnitude apart.

As a result, specifically condemning both sides as Corbyn did seems like an entirely reasonable position to take. Far creepier, indeed, is to minimise one set of atrocities to score political points about something else entirely.

The point I’m making here isn’t really about Corbyn at all. Historically, his position on Northern Ireland has been pro-Republican, rather than pro-peace, and I’d be lying if I said I was entirely comfortable with that.

No, the point I’m making is about the media, and its bias against Labour. Whatever he may have said in the past, whatever may be written on his heart, yesterday morning Jeremy Corbyn condemned IRA bombings. This was the correct thing to do. His words were nonetheless reported as “Jeremy Corbyn refuses to condemn IRA”.

I mean, I don’t generally hold with blaming the mainstream media for politicians’ failures, but it’s a bit rum isn’t it?

Jonn Elledge edits the New Statesman's sister site CityMetric, and writes for the NS about subjects including politics, history and Daniel Hannan. You can find him on Twitter or Facebook.

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