People inside a model of an intestine in Dresden, Germany. Photo: Getty
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Intelligent stomachs: what if your gut could remember what you had eaten?

Welcome to the world of synthetic biology.

Soon, there will be no denying that it was you who finished the milk. Biological engineers at the Massachusetts Institute of Technology (MIT) have tweaked human gut microbes to work as a biochemical memory system. The bacteria are equipped with the equivalent of a computer’s circuit components to encode a record of what you consume into a bacterium’s DNA.

The research isn’t primarily aiming to deduce who ate what, however. The tweaked bacteria take chemical signals from their environment as an input to create outputs that are an indicator of health. They might turn on a fluorescent protein, say, so that laboratory analysis can detect problems.

Researchers suggest that their primary use will be in identifying (and perhaps even treating) bowel disease and colon cancer. It is likely that programmable bacteria will also find other applications. They are, in effect, an in-stomach sensor that could tell your body anything. “Stop eating this stuff – it’s killing you,” they might say.

The bacterium might simply let you know when you have had enough to eat. Or, if you eat the wrong stuff, it could release chemicals that act as painful stimuli. People with addictions could have bacterial reactions – such as nausea – triggered by the problem substance. The bugs could even be made to produce a pharmaceutical treatment in the body: when they detect a problem, they could feasibly synthesise a chemical solution.

It is unfortunate that the field of synthetic biology has adopted a name with negative connotations. The term “synthetic” can trigger concerns similar to those evoked by “genetic modification”. That’s why UK government funding for synthetic biology is now tied to responsible innovation that proceeds while taking public concerns into account. Though the field is led by US researchers, the UK comes in second, producing about a tenth of the world’s output in papers on synthetic biology.

As with genetic modification, there is little need to panic. Indeed, in some areas, synthetic biology should alleviate public concerns. In a paper published this month, German researchers point out that the tools of synthetic biology can do away with the need for transporting dangerous pathogens around the world – a risky practice. Instead, the pathogen’s genome can be sequenced where it is found and its genetic code emailed to labs for re-creation and analysis in a safe environment.

New advances in synthetic biology are arriving all the time. Last month, researchers at Harvard University unveiled a bacterium with a body clock. E coli doesn’t normally have any kind of circadian rhythm, but when the researchers implanted a protein-based clock mechanism from another organism, the E coli turned a fluorescent protein on and off in a regular, 24-hour cycle. It’s a relatively short step from there to having a gut bacterium that will create and release insulin-regulating drugs or other medicines on a daily schedule.

The new work brings this possibility closer. Although E coli is not a great human companion, the bacterium used in the MIT study is a standard, problem-free inhabitant of the human gut. So, synthetic biology has just got personal. It was only last year that Pamela Silver told Harvard Magazine, “Biological machines and biological computers – all of that should soon become a reality.” This is a field that is progressing rapidly. Steal food while you still can.

Michael Brooks holds a PhD in quantum physics. He writes a weekly science column for the New Statesman, and his most recent book is At the Edge of Uncertainty: 11 Discoveries Taking Science by Surprise.

This article first appeared in the 16 July 2015 issue of the New Statesman, The Motherhood Trap

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If the SNP truly want another referendum, the clock is ticking

At party conference in Glasgow, I heard Scotland’s governing party demand a future distinctly different from the one being sketched out in Westminster. 

Nicola Sturgeon described Glasgow as the “dear green city” in her opening address to the SNP party conference, which may surprise anyone raised on a diet of Ken Loach films. In fact, if you’re a fan of faded grandeur and nostalgic parks, there are few places to beat it. My morning walk to conference took me past chipped sandstone tenements, over a bridge across the mysterious, twisting River Kelvin, and through a long avenue of autumnal trees in Kelvingrove Park. In the evenings, the skyline bristled with Victorian Gothic university buildings and church spires, and the hipster bars turned on their lights.

In between these two walks, I heard Scotland’s governing party demand a future distinctly different from the one being sketched out in Westminster. Glasgow’s claim to being the UK’s second city expired long ago but I wonder if, post-Brexit, there might be a case for reviving it.



Scottish politics may never have looked more interesting, but at least one Glasgow taxi driver is already over it. All he hears in the back of his cab is “politics, fitba and religion”, he complained when he picked me up from the station. The message didn’t seem to have reached SNP delegates at the conference centre on the Clyde, who cheered any mention of another referendum.

The First Minister, though, seems to have sensed the nation’s weariness. Support for independence has fallen from 47 per cent in June (Survation) to 39 per cent in October (BMG Research). Sturgeon made headlines with the announcement of a draft referendum bill, but read her speeches carefully and nothing is off the table. SNP politicians made the same demands again and again – devolved control of immigration and access to the single market. None ruled out these happening while remaining in the UK.

If Sturgeon does want a soft Brexit deal, though, she must secure it fast. Most experts agree that it would be far easier for an independent Scotland to inherit Britain’s EU membership than for it to reapply. Once Article 50 is triggered, the SNP will be in a race against the clock.


The hare and the tortoise

If anyone is still in doubt about the SNP’s position, look who won the deputy leadership race. Angus Robertson, the gradualist leader of the party in the Commons, saw off a referendum-minded challenger, Tommy Sheppard, with 52.5 per cent of the vote.

Conference would be nothing without an independence rally, and on the final day supporters gathered for one outside. A stall sold “Indyref 2” T-shirts but the grass-roots members I spoke to were patient, at least for now. William Prowse, resplendent in a kilt and a waistcoat covered in pro-indy
badges, remains supportive of Sturgeon. “The reason she has not called an Indy 2 vote
is we need to have the right numbers,” he told me. “She’s playing the right game.”

Jordi McArthur, a member for 30 years, stood nearby waving a flagpole with the Scottish, Welsh and Catalan flags side by side. “We’re happy to wait until we know what is happening with Brexit,” he said. “But at the same time, we want a referendum. It won’t be Nicola’s choice. It will be the grass roots’ choice.”


No Gerrymandering

Party leaders may come and go, but SNP members can rely on one thing at conference – the stage invasions of the pensioner Gerry Fisher. A legendary dissenter, Fisher refused this year to play along with the party’s embrace of the EU. Clutching the
lectern stubbornly, he told members: “Don’t tell me that you can be independent and a member of the EU. It’s factually rubbish.” In the press room, where conference proceedings were shown unrelentingly on a big screen, hacks stopped what they were doing to cheer him on.


Back to black

No SNP conference would be complete without a glimpse of Mhairi Black, the straight-talking slayer of Douglas Alexander and Westminster’s Baby of the House. She is a celebrity among my millennial friends – a video of her maiden Commons speech has been watched more than 700,000 times – and her relative silence in recent months is making them anxious.

I was determined to track her down, so I set my alarm for an unearthly hour and joined a queue of middle-aged women at an early-morning fringe event. The SNP has taken up the cause of the Waspi (Women Against State Pension Inequality) campaign, run by a group of women born in the 1950s whose retirement age has been delayed and are demanding compensation. Black, who is 22, has become their most ­articulate spokeswoman.

The event started but her chair remained unfilled. When she did arrive, halfway through the session, it was straight from the airport. She gave a rip-roaring speech that momentarily convinced even Waspi sceptics like me, and then dashed off to her next appointment.


Family stories

Woven through the SNP conference was an argument about the benefits of immigration (currently controlled by Westminster). This culminated in an appearance by the Brain family, whose attempt to resist deportation back to Australia has made them a national cause célèbre. (Their young son has learned to speak Gaelic.) Yet for me, the most emotional moment of the conference was when another family, the Chhokars, stepped on stage. Surjit Singh Chhokar was murdered in 1998, but it took 17 years of campaigning and a change in double jeopardy laws before his killer could be brought to justice.

As Aamer Anwar, the family’s solicitor, told the story of “Scotland’s Stephen Lawrence”, Chhokar’s mother and sister stood listening silently, still stricken with grief. After he finished, the delegates gave the family a standing ovation.

Julia Rampen is the editor of The Staggers, the New Statesman’s politics blog

Julia Rampen is the editor of The Staggers, The New Statesman's online rolling politics blog. She was previously deputy editor at Mirror Money Online and has worked as a financial journalist for several trade magazines. 

This article first appeared in the 20 October 2016 issue of the New Statesman, Brothers in blood