Twitter vice-president of products Jason Goldman announced his resignation on Wednesday.
Speaking at the LeWeb Internet conference in Paris, he added that he will still be involved with the microblogging site as an advisor.
He has been the VP of product since joining Twitter in 2007, and he most recently oversaw the launch of 'New Twitter'.
He has also collaborated with co-founder Evan Williams on a blogging start-up that Williams sold to Google in 2003.
Goldman, who oversaw the launch of Twitter's redesign, said he was quitting as he needed a break.
In a tweet just before he left, he listed running SQL during Election 2008 and building a company based on values such as open communication, ambition tempered by humility and bad jokes, as the accomplishments he was proud of during his tenure with Twitter.