NIH study finds two pesticides associated with Parkinsonâ€™s disease
The study was a collaborative effort conducted by researchers at the National Institute of Environmental Health Sciences (NIEHS), which is part of the National Institutes of Health, and the Parkinson's Institute and Clinical Center in Sunnyvale, California.
The authors studied 110 people with Parkinsonâ€™s disease and 358 matched controls from the Farming and Movement Evaluation (FAME) Study to investigate the relationship between Parkinsonâ€™s disease and exposure to pesticides or other agents that are toxic to nervous tissue.
FAME is a case-control study that is part of the larger Agricultural Health Study, a study of farming and health in approximately 90,000 licensed pesticide applicators and their spouses. The investigators diagnosed Parkinson's disease by agreement of movement disorder specialists and assessed the lifelong use of pesticides using detailed interviews.
There are no home garden or residential uses for either paraquat or rotenone currently registered. Paraquat use has long been restricted to certified applicators, largely due to concerns based on studies of animal models of Parkinson's disease. Use of rotenone as a pesticide to kill invasive fish species is currently the only allowable use of this pesticide.
Caroline Tanner, clinical research director of the Parkinsonâ€™s Institute and Clinical Center, and lead author of the article, said: â€œThese findings help us to understand the biologic changes underlying Parkinsonâ€™s disease. This may have important implications for the treatment and ultimately the prevention of Parkinson's disease.â€
Freya Kamel, a researcher in the intramural program at NIEHS and co-author of the paper appearing online in the journal Environmental Health Perspectives, said: "Rotenone directly inhibits the function of the mitochondria, the structure responsible for making energy in the cell. Paraquat increases production of certain oxygen derivatives that may harm cellular structures. People who used these pesticides or others with a similar mechanism of action were more likely to develop Parkinson's disease.â€
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