Why is science doing so poorly in the fight against cancer?

We all know that doing the same thing over and over again and expecting the outcome to change is a mark of insanity. It's time for some fresh ideas on cancer research.

As thousands of women line up to run Cancer Research UK’s Race for Life this summer, few will be aware of how poorly science is doing in the fight against cancer. It’s not something anyone likes to talk about. But now, after years of silence, two dissenters have come along at once.

Few of us are untouched by cancer. If it is not a personal experience, we know someone whose life has been, or is being, affected by this most hideous of life’s processes. Everyone wants to do something about this scourge of modern living. That was why, in 1971, President Nixon declared war on cancer. He had all the confidence of a man whose national space agency had just left human footprints on the moon. Making an impact on cancer has proved much harder, however. We are now better at combating childhood leukaemia than we were, but few other cancers have succumbed to science.

In 1950, cancer killed 193 per 100,000 people. In 2004, the numbers were hardly changed: 186. Many billions of dollars and 54 years of research had saved seven lives out of every 100,000. It’s hardly a success story, especially when compared with the 63 per cent drop in death rates from cardiovascular disease over the same period. We have made a huge difference by using preventative information – getting people to stop smoking and exercise more, for instance. Curing cancer that has already taken hold, though, remains a matter of battering it with chemotherapy and radiotherapy.

Those kinds of figures are why, in 2007, the deputy director of the US National Cancer Institute asked Paul Davies to get involved. Davies is a physicist; speaking of his forays into cancer research at a New Scientist event in London this month, he acknowledged the problems of invading other people’s research territory. Nonetheless, he suggests, a fresh set of brains asking dumb questions is not always a bad thing.

So far, the result of his work with other physicists is to suggest that cancer may be an extremely ancient cellular program that creates a secondary, competing organism within the body. Davies sees the program as a genie in the bottle: when something – stress, or some kind of injury to the cell – breaks the bottle, the genie is released. Spending billions on examining cancer cells is like examining the shards of the bottle while ignoring the genie, Davies reckons.

Just as left-field is Maurice Saatchi’s incursion into the cancer arena. The former ad executive is even less (formally) qualified than Davies to offer critiques of the cancer establishment, but he is far more belligerent. Watching his wife die of ovarian cancer, Saatchi was struck by what he calls the “medieval” nature of the treatment options currently available. In April, he told the New Statesman of his decision to launch a private member’s bill in the House of Lords in order to give doctors more scope to try innovative unlicensed treatments.

The medical research establishment will no doubt scoff at Saatchi’s call; yet it is not always a bad thing to approach a scientific field with the heart as well as the head. The IVF pioneer Robert Edwards was spurred into action by his friendship with a couple who were unable to have children. Whether or not Davies or Saatchi are ultimately successful in their attempts to regain some ground in our fight against cancer is not really the point. The point is to acknowledge that fresh ideas are required.

We all know that doing the same thing over and over again and expecting the outcome to change is a mark of insanity. Let’s end this cancer madness now.

Researchers working at the Cancer Research UK Cambridge Research Institute. Photograph: Getty Images

Michael Brooks holds a PhD in quantum physics. He writes a weekly science column for the New Statesman, and his most recent book is At the Edge of Uncertainty: 11 Discoveries Taking Science by Surprise.

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Calum Kerr on Governing the Digital Economy

With the publication of the UK Digital Strategy we’ve seen another instalment in the UK Government’s ongoing effort to emphasise its digital credentials.

As the SNP’s Digital Spokesperson, there are moves here that are clearly welcome, especially in the area of skills and a recognition of the need for large scale investment in fibre infrastructure.

But for a government that wants Britain to become the “leading country for people to use digital” it should be doing far more to lead on the field that underpins so much of a prosperous digital economy: personal data.

If you want a picture of how government should not approach personal data, just look at the Concentrix scandal.

Last year my constituency office, like countless others across the country, was inundated by cases from distressed Tax Credit claimants, who found their payments had been stopped for spurious reasons.

This scandal had its roots in the UK’s current patchwork approach to personal data. As a private contractor, Concentrix had bought data on a commercial basis and then used it to try and find undeclared partners living with claimants.

In one particularly absurd case, a woman who lived in housing provided by the Joseph Rowntree Foundation had to resort to using a foodbank during the appeals process in order to prove that she did not live with Joseph Rowntree: the Quaker philanthropist who died in 1925.

In total some 45,000 claimants were affected and 86 per cent of the resulting appeals saw the initial decision overturned.

This shows just how badly things can go wrong if the right regulatory regimes are not in place.

In part this problem is a structural one. Just as the corporate world has elevated IT to board level and is beginning to re-configure the interface between digital skills and the wider workforce, government needs to emulate practices that put technology and innovation right at the heart of the operation.

To fully leverage the benefits of tech in government and to get a world-class data regime in place, we need to establish a set of foundational values about data rights and citizenship.

Sitting on the committee of the Digital Economy Bill, I couldn’t help but notice how the elements relating to data sharing, including with private companies, were rushed through.

The lack of informed consent within the Bill will almost certainly have to be looked at again as the Government moves towards implementing the EU’s General Data Protection Regulation.

This is an example of why we need democratic oversight and an open conversation, starting from first principles, about how a citizen’s data can be accessed.

Personally, I’d like Scotland and the UK to follow the example of the Republic of Estonia, by placing transparency and the rights of the citizen at the heart of the matter, so that anyone can access the data the government holds on them with ease.

This contrasts with the mentality exposed by the Concentrix scandal: all too often people who come into contact with the state are treated as service users or customers, rather than as citizens.

This paternalistic approach needs to change.  As we begin to move towards the transformative implementation of the internet of things and 5G, trust will be paramount.

Once we have that foundation, we can start to grapple with some of the most pressing and fascinating questions that the information age presents.

We’ll need that trust if we want smart cities that make urban living sustainable using big data, if the potential of AI is to be truly tapped into and if the benefits of digital healthcare are really going to be maximised.

Clearly getting accepted ethical codes of practice in place is of immense significance, but there’s a whole lot more that government could be doing to be proactive in this space.

Last month Denmark appointed the world’s first Digital Ambassador and I think there is a compelling case for an independent Department of Technology working across all government departments.

This kind of levelling-up really needs to be seen as a necessity, because one thing that we can all agree on is that that we’ve only just scratched the surface when it comes to developing the link between government and the data driven digital economy. 

In January, Hewlett Packard Enterprise and the New Statesman convened a discussion on this topic with parliamentarians from each of the three main political parties and other experts.  This article is one of a series from three of the MPs who took part, with an  introduction from James Johns of HPE, Labour MP, Angela Eagle’s view and Conservative MP, Matt Warman’s view

Calum Kerr is SNP Westminster Spokesperson for Digital