Why is science doing so poorly in the fight against cancer?

We all know that doing the same thing over and over again and expecting the outcome to change is a mark of insanity. It's time for some fresh ideas on cancer research.

As thousands of women line up to run Cancer Research UK’s Race for Life this summer, few will be aware of how poorly science is doing in the fight against cancer. It’s not something anyone likes to talk about. But now, after years of silence, two dissenters have come along at once.

Few of us are untouched by cancer. If it is not a personal experience, we know someone whose life has been, or is being, affected by this most hideous of life’s processes. Everyone wants to do something about this scourge of modern living. That was why, in 1971, President Nixon declared war on cancer. He had all the confidence of a man whose national space agency had just left human footprints on the moon. Making an impact on cancer has proved much harder, however. We are now better at combating childhood leukaemia than we were, but few other cancers have succumbed to science.

In 1950, cancer killed 193 per 100,000 people. In 2004, the numbers were hardly changed: 186. Many billions of dollars and 54 years of research had saved seven lives out of every 100,000. It’s hardly a success story, especially when compared with the 63 per cent drop in death rates from cardiovascular disease over the same period. We have made a huge difference by using preventative information – getting people to stop smoking and exercise more, for instance. Curing cancer that has already taken hold, though, remains a matter of battering it with chemotherapy and radiotherapy.

Those kinds of figures are why, in 2007, the deputy director of the US National Cancer Institute asked Paul Davies to get involved. Davies is a physicist; speaking of his forays into cancer research at a New Scientist event in London this month, he acknowledged the problems of invading other people’s research territory. Nonetheless, he suggests, a fresh set of brains asking dumb questions is not always a bad thing.

So far, the result of his work with other physicists is to suggest that cancer may be an extremely ancient cellular program that creates a secondary, competing organism within the body. Davies sees the program as a genie in the bottle: when something – stress, or some kind of injury to the cell – breaks the bottle, the genie is released. Spending billions on examining cancer cells is like examining the shards of the bottle while ignoring the genie, Davies reckons.

Just as left-field is Maurice Saatchi’s incursion into the cancer arena. The former ad executive is even less (formally) qualified than Davies to offer critiques of the cancer establishment, but he is far more belligerent. Watching his wife die of ovarian cancer, Saatchi was struck by what he calls the “medieval” nature of the treatment options currently available. In April, he told the New Statesman of his decision to launch a private member’s bill in the House of Lords in order to give doctors more scope to try innovative unlicensed treatments.

The medical research establishment will no doubt scoff at Saatchi’s call; yet it is not always a bad thing to approach a scientific field with the heart as well as the head. The IVF pioneer Robert Edwards was spurred into action by his friendship with a couple who were unable to have children. Whether or not Davies or Saatchi are ultimately successful in their attempts to regain some ground in our fight against cancer is not really the point. The point is to acknowledge that fresh ideas are required.

We all know that doing the same thing over and over again and expecting the outcome to change is a mark of insanity. Let’s end this cancer madness now.

Researchers working at the Cancer Research UK Cambridge Research Institute. Photograph: Getty Images

Michael Brooks holds a PhD in quantum physics. He writes a weekly science column for the New Statesman, and his most recent book is At the Edge of Uncertainty: 11 Discoveries Taking Science by Surprise.

Paul McMillan
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"We're an easy target": how a Tory manifesto pledge will tear families apart

Under current rules, bringing your foreign spouse to the UK is a luxury reserved for those earning £18,600 a year or more. The Tories want to make it even more exclusive. 

Carolyn Matthew met her partner, George, in South Africa sixteen years ago. She settled down with him, had kids, and lived like a normal family until last year, when they made the fateful decision to move to her hometown in Scotland. Matthew, 55, had elderly parents, and after 30 years away from home she wanted to be close to them. 

But Carolyn nor George - despite consulting a South African immigration lawyer – did not anticipate one huge stumbling block. That is the rule, introduced in 2012, that a British citizen must earn £18,600 a year before a foreign spouse may join them in the UK. 

“It is very dispiriting,” Carolyn said to me on the telephone from Bo’ness, a small town on the Firth of Forth, near Falkirk. “In two weeks, George has got to go back to South Africa.” Carolyn, who worked in corporate complaints, has struggled to find the same kind of work in her hometown. Jobs at the biggest local employer tend to be minimum wage. George, on the other hand, is an engineer – yet cannot work because of his holiday visa. 

To its critics, the minimum income threshold seems nonsensical. It splits up families – including children from parents – and discriminates against those likely to earn lower wages, such as women, ethnic minorities and anyone living outside London and the South East. The Migration Observatory has calculated that roughly half Britain’s working population would not meet the requirement. 

Yet the Conservative party not only wishes to maintain the policy, but hike the threshold. The manifesto stated:  “We will increase the earnings thresholds for people wishing to sponsor migrants for family visas.” 

Initially, the threshold was justified as a means of preventing foreign spouses from relying on the state. But tellingly, the Tory manifesto pledge comes under the heading of “Controlling Immigration”. 

Carolyn points out that because George cannot work while he is visiting her, she must support the two of them for months at a time without turning to state aid. “I don’t claim benefits,” she told me. “That is the last thing I want to do.” If both of them could work “life would be easy”. She believes that if the minimum income threshold is raised any further "it is going to make it a nightmare for everyone".

Stuart McDonald, the SNP MP for Cumbernauld, Kilsyth and Kirkintilloch East, co-sponsored a Westminster Hall debate on the subject earlier this year. While the Tory manifesto pledge is vague, McDonald warns that one option is the highest income threshold suggested in 2012 - £25,700, or more than the median yearly wage in the East Midlands. 

He described the current scheme as “just about the most draconian family visa rules in the world”, and believes a hike could affect more than half of British citizens. 

"Theresa May is forcing people to choose between their families and their homes in the UK - a choice which most people will think utterly unfair and unacceptable,” he said.  

For those a pay rise away from the current threshold, a hike will be demoralising. For Paul McMillan, 25, it is a sign that it’s time to emigrate.

McMillan, a graduate, met his American girlfriend Megan while travelling in 2012 (the couple are pictured above). He could find a job that will allow him to meet the minimum income threshold – if he were not now studying for a medical degree.  Like Matthew, McMillan’s partner has no intention of claiming benefits – in fact, he expects her visa would specifically ban her from doing so. 

Fed up with the hostile attitude to immigrants, and confident of his options elsewhere, McMillan is already planning a career abroad. “I am going to take off in four years,” he told me. 

As for why the Tories want to raise the minimum income threshold, he thinks it’s obvious – to force down immigration numbers. “None of this is about the amount of money we need to earn,” he said. “We’re an easy target for the government.”

Julia Rampen is the digital news editor of the New Statesman (previously editor of The Staggers, The New Statesman's online rolling politics blog). She has also been deputy editor at Mirror Money Online and has worked as a financial journalist for several trade magazines. 

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