Why is science doing so poorly in the fight against cancer?

We all know that doing the same thing over and over again and expecting the outcome to change is a mark of insanity. It's time for some fresh ideas on cancer research.

As thousands of women line up to run Cancer Research UK’s Race for Life this summer, few will be aware of how poorly science is doing in the fight against cancer. It’s not something anyone likes to talk about. But now, after years of silence, two dissenters have come along at once.

Few of us are untouched by cancer. If it is not a personal experience, we know someone whose life has been, or is being, affected by this most hideous of life’s processes. Everyone wants to do something about this scourge of modern living. That was why, in 1971, President Nixon declared war on cancer. He had all the confidence of a man whose national space agency had just left human footprints on the moon. Making an impact on cancer has proved much harder, however. We are now better at combating childhood leukaemia than we were, but few other cancers have succumbed to science.

In 1950, cancer killed 193 per 100,000 people. In 2004, the numbers were hardly changed: 186. Many billions of dollars and 54 years of research had saved seven lives out of every 100,000. It’s hardly a success story, especially when compared with the 63 per cent drop in death rates from cardiovascular disease over the same period. We have made a huge difference by using preventative information – getting people to stop smoking and exercise more, for instance. Curing cancer that has already taken hold, though, remains a matter of battering it with chemotherapy and radiotherapy.

Those kinds of figures are why, in 2007, the deputy director of the US National Cancer Institute asked Paul Davies to get involved. Davies is a physicist; speaking of his forays into cancer research at a New Scientist event in London this month, he acknowledged the problems of invading other people’s research territory. Nonetheless, he suggests, a fresh set of brains asking dumb questions is not always a bad thing.

So far, the result of his work with other physicists is to suggest that cancer may be an extremely ancient cellular program that creates a secondary, competing organism within the body. Davies sees the program as a genie in the bottle: when something – stress, or some kind of injury to the cell – breaks the bottle, the genie is released. Spending billions on examining cancer cells is like examining the shards of the bottle while ignoring the genie, Davies reckons.

Just as left-field is Maurice Saatchi’s incursion into the cancer arena. The former ad executive is even less (formally) qualified than Davies to offer critiques of the cancer establishment, but he is far more belligerent. Watching his wife die of ovarian cancer, Saatchi was struck by what he calls the “medieval” nature of the treatment options currently available. In April, he told the New Statesman of his decision to launch a private member’s bill in the House of Lords in order to give doctors more scope to try innovative unlicensed treatments.

The medical research establishment will no doubt scoff at Saatchi’s call; yet it is not always a bad thing to approach a scientific field with the heart as well as the head. The IVF pioneer Robert Edwards was spurred into action by his friendship with a couple who were unable to have children. Whether or not Davies or Saatchi are ultimately successful in their attempts to regain some ground in our fight against cancer is not really the point. The point is to acknowledge that fresh ideas are required.

We all know that doing the same thing over and over again and expecting the outcome to change is a mark of insanity. Let’s end this cancer madness now.

Researchers working at the Cancer Research UK Cambridge Research Institute. Photograph: Getty Images

Michael Brooks holds a PhD in quantum physics. He writes a weekly science column for the New Statesman, and his most recent book is At the Edge of Uncertainty: 11 Discoveries Taking Science by Surprise.

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BHS is Theresa May’s big chance to reform capitalism – she’d better take it

Almost everyone is disgusted by the tale of BHS. 

Back in 2013, Theresa May gave a speech that might yet prove significant. In it, she declared: “Believing in free markets doesn’t mean we believe that anything goes.”

Capitalism wasn’t perfect, she continued: 

“Where it’s manifestly failing, where it’s losing public support, where it’s not helping to provide opportunity for all, we have to reform it.”

Three years on and just days into her premiership, May has the chance to be a reformist, thanks to one hell of an example of failing capitalism – BHS. 

The report from the Work and Pensions select committee was damning. Philip Green, the business tycoon, bought BHS and took more out than he put in. In a difficult environment, and without new investment, it began to bleed money. Green’s prize became a liability, and by 2014 he was desperate to get rid of it. He found a willing buyer, Paul Sutton, but the buyer had previously been convicted of fraud. So he sold it to Sutton’s former driver instead, for a quid. Yes, you read that right. He sold it to a crook’s driver for a quid.

This might all sound like a ludicrous but entertaining deal, if it wasn’t for the thousands of hapless BHS workers involved. One year later, the business collapsed, along with their job prospects. Not only that, but Green’s lack of attention to the pension fund meant their dreams of a comfortable retirement were now in jeopardy. 

The report called BHS “the unacceptable face of capitalism”. It concluded: 

"The truth is that a large proportion of those who have got rich or richer off the back of BHS are to blame. Sir Philip Green, Dominic Chappell and their respective directors, advisers and hangers-on are all culpable. 

“The tragedy is that those who have lost out are the ordinary employees and pensioners.”

May appears to agree. Her spokeswoman told journalists the PM would “look carefully” at policies to tackle “corporate irresponsibility”. 

She should take the opportunity.

Attempts to reshape capitalism are almost always blunted in practice. Corporations can make threats of their own. Think of Google’s sweetheart tax deals, banks’ excessive pay. Each time politicians tried to clamp down, there were threats of moving overseas. If the economy weakens in response to Brexit, the power to call the shots should tip more towards these companies. 

But this time, there will be few defenders of the BHS approach.

Firstly, the report's revelations about corporate governance damage many well-known brands, which are tarnished by association. Financial services firms will be just as keen as the public to avoid another BHS. Simon Walker, director general of the Institute of Directors, said that the circumstances of the collapse of BHS were “a blight on the reputation of British business”.

Secondly, the pensions issue will not go away. Neglected by Green until it was too late, the £571m hole in the BHS pension finances is extreme. But Tom McPhail from pensions firm Hargreaves Lansdown has warned there are thousands of other defined benefit schemes struggling with deficits. In the light of BHS, May has an opportunity to take an otherwise dusty issue – protections for workplace pensions - and place it top of the agenda. 

Thirdly, the BHS scandal is wreathed in the kind of opaque company structures loathed by voters on the left and right alike. The report found the Green family used private, offshore companies to direct the flow of money away from BHS, which made it in turn hard to investigate. The report stated: “These arrangements were designed to reduce tax bills. They have also had the effect of reducing levels of corporate transparency.”

BHS may have failed as a company, but its demise has succeeded in uniting the left and right. Trade unionists want more protection for workers; City boys are worried about their reputation; patriots mourn the death of a proud British company. May has a mandate to clean up capitalism - she should seize it.