Mean Broadcast will be led by Letzer and de Napoli as managing partners.
The company's inaugural clients include Matchroom Sport, Square I Media, Marvel Comics and Simply Media.
Martin McAleese, head of digital at Ten Alps, has been appointed as the sales director at Mean Broadcast. He is currently recruiting sales staff.
Barry Hearn, chairman of Matchroom Sport, said that Mean Broadcast was a "commercially-minded agency that can identify the opportunities and then make the connections to create commercial partnerships with the right advertisers".