The Compatibility Gene by Daniel M Davis: "I am very rare but my wife is rather common"

The scientist Daniel M Davis has told the story of genetic compatibility - and the rejection that is its opposite - with great insight and decades of research. It's a field that may yield significant treasures in the decades to come.

The Compatibility Gene
Daniel M Davis
Allen Lane, 256pp, £20

“I am very rare but my wife is rather common.” This is not a sentence that would normally endear an author to you, let alone make you feel a little sorry for him. The thing is, it’s not great being exotic. Should Daniel M Davis get seriously ill, his chances of finding a transplant match are very bad. When he tells you that his wife is not one in a million but one in 100,000, you should feel good for her. Davis is one in four million, according to the genetic tests that the couple underwent. That’s very bad news, transplant-wise.

This all comes down to what Davis terms the “compatibility genes”. They are the set of genes that determine the make-up of your immune system and make you who you are.

We worry about where we came from. There is not a human civilisation on the planet that does not pay attention to its ancestors in some way. TV genealogy shows have probably amplified this trait, encouraging us to treasure our roots (or despair at them) in ever larger measure. So it’s no wonder we don’t cope well with the idea of organ transplantation: it messes with everything.

A study carried out in Sweden demonstrates the problem. In interviews with patients who had received someone else’s kidney, almost all of the subjects said that they felt it was best not to know too much about the donor. For some irrational, inexplicable reason, we are psychologically sideswiped by the idea that someone else’s meat has been installed inside our own. Some patients even worried about worrying about it, expressing a fear that too much “brooding” over the donor could lead their bodies to reject the foreign tissue.

We now know, thanks to a half-century of scientific sleuthing, that this isn’t true. Rejection of foreign bodies results from the activities of the compatibility genes. Davis’s enlightening book tells the extraordinary story of that discovery. As well as dealing with foreign tissue, the compatibility genes seem to influence our selection of biologically beneficial partners. It turns out that we look for complementary immune systems that enhance the chance of our offspring’s survival. Get it wrong at your peril: the compatibility genes are, it seems, frequently to blame in miscarriages. The contributions frommother and father have to be a good complementary pairing for a pregnancy to be successful. If Davis’s wife had chosen a more “common” man, she might have found herself with someone whose genes were too similar to her own, with adverse effects on the couple’s fertility. As Davis puts it, “Differences in our immune-system genes can influence who gets born.”

Sadly, science has not yet given us ways to cope with these differences. The best you can do is try to find a partner who somehow smells right. Evolution’s finest innovation might be the nose: we use it to check whether someone else’s immune system is complementary to our own.

Evolution is not perfect, however: given that as many as one in three pregnancies ends in miscarriage, cleary the smell is too subtle. Either that or we are all washing too thoroughly (or not doing enough investigative snogging).

It is almost ironic that the scientists who laid the foundations of this kind of research also had coupling issues. The Nobel laureate biologist Peter Medawar’s work elucidating what causes the rejection of transplants was so intense that he told his wife that she had claim on his love but not his time (and that he would be fine with an open marriage). The Danish biologist and sadomasochism fan Niels Jerne had a string of affairs before his wife (who had her share of lovers) committed suicide; it was only later, suppressing his grief with a gruelling work schedule, that Jerne uncovered the protective powers of antibodies. The Austrian Karl Landsteiner discovered the vital distinctions we know as blood groups. He also lived with his mother until she died. When he married shortly after that, the new Mrs Landsteiner faced the nightly distraction of her mother-in-law’s death mask on the bedroom wall. To her credit, the couple did manage to have a child.

Many more scientists are threaded through the pages of Davis’s thoughtful book and they all share one thing: the grinding heartbreak that is the slow progress of scientific discovery. It’s a heartbreak that Davis knows well; he is a leading figure in this subject. Though the science behind what causes our body to recognise itself and reject foreign material is more than 60 years old, he tells us, the conclusions we can draw from it are still fairly limited. Nonetheless, The Compatibility Gene is a fascinating, expertly told story of a field that may yield significant treasures in the decades to come.

Michael Brooks is the New Statesman’s science columnist 

The science behind our bodies' rejection of foreign material is 60 years old, Davis writes, but the conclusions we can draw are still limited. Photograph: Getty Images.

Michael Brooks holds a PhD in quantum physics. He writes a weekly science column for the New Statesman, and his most recent book is At the Edge of Uncertainty: 11 Discoveries Taking Science by Surprise.

This article first appeared in the 02 September 2013 issue of the New Statesman, Syria: The west humiliated

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Celluloid Dreams: are film scores the next area of serious musical scholarship?

John Wilson has little time for people who don't see the genius at work in so-called "light music".

When John Wilson walks out on to the stage at the Royal Albert Hall in London, there is a roar from the audience that would be more fitting in a football stadium. Before he even steps on to the conductor’s podium, people whistle and cheer, thumping and clapping. The members of his orchestra grin as he turns to acknowledge the applause. Many soloists reaching the end of a triumphant concerto performance receive less ecstatic praise. Even if you had never heard of Wilson before, the rock-star reception would tip you off that you were about to hear something special.

There is a moment of silence as Wilson holds the whole hall, audience and orchestra alike, in stasis, his baton raised expectantly. Then it slices down and the orchestra bursts into a tightly controlled mass of sound, complete with swirling strings and blowsy brass. You are instantly transported: this is the music to which Fred Astaire and Ginger Rogers danced, the music of George Gershwin, Cole Porter, Irving Berlin, which reverberated around the cauldron of creativity that was Hollywood of the early 20th century, when composers were as sought after as film directors.

Wilson’s shows are tremendously popular. Since he presented the MGM musicals programme at the Proms in 2009, which was watched by 3.5 million people on TV and is still selling on DVD, his concerts have been among the first to sell out in every Proms season. There are international tours and popular CDs, too. But a great deal of behind-the-scenes work goes into bringing this music – much of which had been lost to history – back to life. There are familiar tunes among the complex arrangements that he and his orchestra play, to be sure, but the music sounds fresher and sharper than it ever does on old records or in movies. Whether you’re a film fan or not, you will find something about the irrepressible energy of these tunes that lifts the spirits.

Sitting in an armchair in the conductor’s room beneath the Henry Wood Hall in south London, Wilson looks anything but energetic. “Excuse my yawning, but I’ve been up since three o’clock this morning,” he says. This is a short break in a hectic rehearsal schedule, as he puts his orchestra through its paces in the lead-up to its appearance at the 2016 Proms. Watching him at work before we sat down to talk, I saw a conductor who was far from sluggish. Bobbing on the balls of his feet, he pushed his players to consider every detail of their sound, often stopping the musicians to adjust the tone of a single note or phrase. At times, his whole body was tense with the effort of communicating the tone he required.

The programme that Wilson and his orchestra are obsessing over at the moment is a celebration of George and Ira Gershwin, the American songwriting partnership that produced such immortal songs as “I Got Rhythm”, “’S Wonderful” and “Funny Face”, as well as the 1934 opera Porgy and Bess. Though it might all sound effortless when everyone finally appears in white tie, huge amounts of preparation go into a John Wilson concert and they start long before the orchestra begins to rehearse.

“Coming up with the idea is the first step,” he says. “Then you put a programme together, which takes a great deal of time and thought and revision. You can go through 40 drafts until you get it right. I was still fiddling with the running order two weeks ago. It’s like a three-dimensional game of chess – one thing changes and the whole lot comes down.”

Wilson, 44, who also conducts the more conventional classical repertoire, says that his interest in so-called light music came early on. “When you’re a kid, you don’t know that you shouldn’t like the Beatles, or you shouldn’t like Fred Astaire, or whatever,” he says. “You just like anything that’s good. So I grew up loving Beethoven and Brahms and Ravel and Frank Sinatra and the Beatles.” At home in Gateshead – he still has the Geordie accent – the only music in the house was “what was on the radio and telly”, and the young boy acquired his taste from what he encountered playing with local brass bands and amateur orchestras.

He had the opposite of the hothoused, pressured childhood that we often associate with professional musicians. “Mine were just nice, lovely, normal parents! As long as I wore clean underwear and finished my tea, then they were happy,” he recalls. “I was never forced into doing music. My parents used to have to sometimes say, ‘Look, you’ve played the piano enough today; go out and get some fresh air’ – things like that.” Indeed, he received barely any formal musical education until he went to the Royal College of Music at the age of 18, after doing his A-levels at Newcastle College.

The title of the concert he conducted at this year’s Proms was “George and Ira Gershwin Rediscovered”, which hints at the full scale of Wilson’s work. Not only does he select his music from the surviving repertoire of 20th-century Hollywood: in many cases, he unearths scores that weren’t considered worth keeping at the time and resurrects the music into a playable state. At times, there is no written trace at all and he must reconstruct a score by ear from a ­recording or the soundtrack of a film.

For most other musicians, even experts, it would be an impossible task. Wilson smiles ruefully when I ask how he goes about it. “There are 18 pieces in this concert. Only six of them exist in full scores. So you track down whatever materials survive, whether they be piano or conductors’ scores or recordings, and then my colleagues and I – there are four of us – sit down with the scores.” There is no hard and fast rule for how to do this kind of reconstruction, he says, as it depends entirely on what there is left to work with. “It’s like putting together a jigsaw, or a kind of archaeology. You find whatever bits you can get your hands on. But the recording is always the final word: that’s the ur-text. That is what you aim to replicate, because that represents the composer’s and lyricist’s final thoughts.” There is a purpose to all this effort that goes beyond putting on a great show, though that is a big part of why Wilson does it. “I just want everyone to leave with the thrill of having experienced the sound of a live orchestra,” he says earnestly. “I tell the orchestra, ‘Never lose sight of the fact that people have bought tickets, left the house, got on the bus/Tube, come to the concert. Give them their money’s worth. Play every last quaver with your lifeblood.’”

Besides holding to a commitment to entertain, Wilson believes there is an academic justification for the music. “These composers were working with expert ­arrangers, players and singers . . . It’s a wonderful period of music. I think it’s the next major area of serious musical scholarship.”

These compositions sit in a strange, in-between place. Classical purists deride them as “light” and thus not worthy of attention, while jazz diehards find the catchy syncopations tame and conventional. But he has little time for anyone who doesn’t recognise the genius at work here. “They’re art songs, is what they are. The songs of Gershwin and Porter and [Jerome] Kern are as important to their period as the songs of Schubert . . . People who are sniffy about this material don’t really know it, as far as I’m concerned, because I’ve never met a musician of any worth who’s sniffy about this.

Selecting the right performers is another way in which Wilson ensures that his rediscovered scores will get the best possible presentation. He formed the John Wilson Orchestra in 1994, while he was still studying at the Royal College of Music, with the intention of imitating the old Hollywood studio orchestras that originally performed this repertoire. Many of the players he works with are stars of other European orchestras – in a sense, it is a supergroup. The ensemble looks a bit like a symphony orchestra with a big band nestled in the middle – saxophones next to French horns and a drum kit in the centre. The right string sound, in particular, is essential.

At the rehearsal for the Gershwin programme, I heard Wilson describing to the first violins exactly what he wanted: “Give me the hottest sound you’ve made since your first concerto at college.” Rather than the blended tone that much of the classical repertoire calls for, this music demands throbbing, emotive, swooping strings. Or, as Wilson put it: “Use so much vibrato that people’s family photos will shuffle across the top of their TVs and fall off.”

His conducting work spans much more than his Hollywood musical reconstruction projects. Wilson is a principal conductor with the Royal Northern Sinfonia and has performed or recorded with most of the major ensembles in Britain. And his great passion is for English music: the romanticism of Elgar, Vaughan Williams and Delius needs advocates, too, he says. He insists that these two strands of his career are of equivalent importance. “I make no separation between my activities conducting classical music and [film scores]. They’re just all different rooms in the same house.” 

The John Wilson Orchestra’s “Gershwin in Hollywood” (Warner Classics) is out now

Caroline Crampton is assistant editor of the New Statesman.

This article first appeared in the 25 August 2016 issue of the New Statesman, Cameron: the legacy of a loser