The Compatibility Gene by Daniel M Davis: "I am very rare but my wife is rather common"

The scientist Daniel M Davis has told the story of genetic compatibility - and the rejection that is its opposite - with great insight and decades of research. It's a field that may yield significant treasures in the decades to come.

The Compatibility Gene
Daniel M Davis
Allen Lane, 256pp, £20

“I am very rare but my wife is rather common.” This is not a sentence that would normally endear an author to you, let alone make you feel a little sorry for him. The thing is, it’s not great being exotic. Should Daniel M Davis get seriously ill, his chances of finding a transplant match are very bad. When he tells you that his wife is not one in a million but one in 100,000, you should feel good for her. Davis is one in four million, according to the genetic tests that the couple underwent. That’s very bad news, transplant-wise.

This all comes down to what Davis terms the “compatibility genes”. They are the set of genes that determine the make-up of your immune system and make you who you are.

We worry about where we came from. There is not a human civilisation on the planet that does not pay attention to its ancestors in some way. TV genealogy shows have probably amplified this trait, encouraging us to treasure our roots (or despair at them) in ever larger measure. So it’s no wonder we don’t cope well with the idea of organ transplantation: it messes with everything.

A study carried out in Sweden demonstrates the problem. In interviews with patients who had received someone else’s kidney, almost all of the subjects said that they felt it was best not to know too much about the donor. For some irrational, inexplicable reason, we are psychologically sideswiped by the idea that someone else’s meat has been installed inside our own. Some patients even worried about worrying about it, expressing a fear that too much “brooding” over the donor could lead their bodies to reject the foreign tissue.

We now know, thanks to a half-century of scientific sleuthing, that this isn’t true. Rejection of foreign bodies results from the activities of the compatibility genes. Davis’s enlightening book tells the extraordinary story of that discovery. As well as dealing with foreign tissue, the compatibility genes seem to influence our selection of biologically beneficial partners. It turns out that we look for complementary immune systems that enhance the chance of our offspring’s survival. Get it wrong at your peril: the compatibility genes are, it seems, frequently to blame in miscarriages. The contributions frommother and father have to be a good complementary pairing for a pregnancy to be successful. If Davis’s wife had chosen a more “common” man, she might have found herself with someone whose genes were too similar to her own, with adverse effects on the couple’s fertility. As Davis puts it, “Differences in our immune-system genes can influence who gets born.”

Sadly, science has not yet given us ways to cope with these differences. The best you can do is try to find a partner who somehow smells right. Evolution’s finest innovation might be the nose: we use it to check whether someone else’s immune system is complementary to our own.

Evolution is not perfect, however: given that as many as one in three pregnancies ends in miscarriage, cleary the smell is too subtle. Either that or we are all washing too thoroughly (or not doing enough investigative snogging).

It is almost ironic that the scientists who laid the foundations of this kind of research also had coupling issues. The Nobel laureate biologist Peter Medawar’s work elucidating what causes the rejection of transplants was so intense that he told his wife that she had claim on his love but not his time (and that he would be fine with an open marriage). The Danish biologist and sadomasochism fan Niels Jerne had a string of affairs before his wife (who had her share of lovers) committed suicide; it was only later, suppressing his grief with a gruelling work schedule, that Jerne uncovered the protective powers of antibodies. The Austrian Karl Landsteiner discovered the vital distinctions we know as blood groups. He also lived with his mother until she died. When he married shortly after that, the new Mrs Landsteiner faced the nightly distraction of her mother-in-law’s death mask on the bedroom wall. To her credit, the couple did manage to have a child.

Many more scientists are threaded through the pages of Davis’s thoughtful book and they all share one thing: the grinding heartbreak that is the slow progress of scientific discovery. It’s a heartbreak that Davis knows well; he is a leading figure in this subject. Though the science behind what causes our body to recognise itself and reject foreign material is more than 60 years old, he tells us, the conclusions we can draw from it are still fairly limited. Nonetheless, The Compatibility Gene is a fascinating, expertly told story of a field that may yield significant treasures in the decades to come.

Michael Brooks is the New Statesman’s science columnist 

The science behind our bodies' rejection of foreign material is 60 years old, Davis writes, but the conclusions we can draw are still limited. Photograph: Getty Images.

Michael Brooks holds a PhD in quantum physics. He writes a weekly science column for the New Statesman, and his most recent book is At the Edge of Uncertainty: 11 Discoveries Taking Science by Surprise.

This article first appeared in the 02 September 2013 issue of the New Statesman, Syria: The west humiliated

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Defining The Defenders: the long history of the superhero team-up

Netflix's new show draws on an established traditon of bringing together disparate characters.

Today Marvel’s The Defenders dropped worldwide. It’s the culmination of Marvel Studios’ interlinked series for Netflix, and all episodes will be available simultaneously as is the streaming services’ wont.

The Defenders, and the Netflix series that have preceded it, seem modelled on how the Marvel Cinematic Universe films have worked in multiplexes. At least superficially. Characters get their own solo films/series, which become increasingly interlinked over time, before all featuring together in an onscreen ‘team up’. Here, they combine against a threat greater than any they could plausibly win against on their own, sparring and generating alliances, friendships and even enmities in the process.

This structure, of course, is Marvel’s film and TV projects aping their source material. Marvel’s comics, and superhero comics more generally, have long relished the "team up" and the "super team". The use of this approach by Marvel’s other media ventures is intuitively right, allowing the mass audience for film and television to experience one of the specific pleasures of how superhero comics work in the characters’ new medium.

The concept of the super team goes back a long way. The Justice Society of America, from Marvel’s Distinguished Competition, is usually considered the first. They debuted in All-Star Comics #3 (1940) and the team consisted of the Flash (the Jay Garrick version, Flash TV fans), Green Lantern, Hawkman, and now lesser known characters like Hour-Man, the Sandman (not the Neil Gaiman one), the Atom, The Spectre and Doctor Fate. Within a few issues Wonder Woman would join: as secretary. Because it was the 1940s.

What’s interesting about this initial super team is that half of these characters were published by All-American Comics (who actually published All-Star) and half by DC Comics themselves, making this an inter-company crossover. (The companies would later merge). It also used to be claimed as the first example of characters created separately, and with no intention of them being connected, interacting. It isn’t. There are countless examples in the pulp fictions of the late nineteenth century, but the claim stood for so long because it felt right that the original super team should be the source of such meta-fictional innovation.

The Defenders were created much later in comics history and first appeared in 1971’s Marvel Feature #1. The team, though, had its origins in the "Titans Three" an informal grouping of heroes who appeared in a three part story serialised across Doctor Strange #183 (November 1969), Sub-Mariner #22 (February 1970), and The Incredible Hulk #126 (April 1970).

All three of those comics were written by Roy Thomas. Caught on the hop by the sudden cancellation of Doctor Strange (#183 was the final issue), he wrapped up ongoing plotlines from the cancelled comic in other series he scripted, bringing the now title-less Strange into those other series in the process. A couple more appearances of the group together followed, before the team was formally named in the aforementioned Marvel Feature #1.

Dr Strange. The Sub-Mariner. The Incredible Hulk. It’s quite likely that anyone reading this who is only familiar with the publicity for Netflix’s The Defenders would be surprised by that roster of headline characters. (And that’s assuming they’re even familiar with Namor the Sub-Mariner, a character of 1939 vintage who has not yet reached the MCU.) This is a radically different group to Daredevil, Jessica Jones (a character not even created until the 21st century), Luke Cage and Iron Fist, the stars of the current TV series. None of the telly team are characters a Marvel zombie would associate with The Defenders, although Iron Fist has been a very occasional member of the team’s roster, as has Luke Cage. (In which context, it’s unfortunate that Iron Fist has been the least liked of Netflix’s series, with a mere 17 per cent approval on Rotten Tomatoes.)

The complete absence of all three of the original Defenders from its television incarnation could be seen as an odd decision. Neither Benedict Cumberbatch’s Steven Strange nor Mark Ruffalo’s Bruce Banner are expected to turn up, even for cameos. Marvel Studios has policed a strict division between its Netflix series and its cinematic outings, despite announcing them as being set in the same "continuity". The fourth "classic" Defender is even less likely to turn up. The Silver Surfer (who joined the team in 1972, less than a year after it was formed) is, due to some bad deal making in the 90s, off limits to the MCU. His film rights sit with Fox, who utilised him in the rightly all but forgotten Fantastic Four: Rise of the Silver Surfer (2007). 

One of the reasonably consistent features of previous incarnations of The Defenders is that the characters have generally faced mystical threats. They first teamed up to fight monsters from HP Lovecraft’s Cthulhu Mythos, and generally their antagonists have operated on that kind of scale. With Stephen Strange in the gang, that makes sense. You don’t need the sorcerer supreme to take out organised crime. But organised crime is largely what you’d expect Daredevil, Luke Cage, Jessica Jones and Iron Fist to take on, especially based on the Netflix versions of the characters. All four are "street-level" heroes, operating in New York, interacting with characters like murderous vigilante The Punisher and Kingpin of Crime Wilson Fisk. Perhaps splitting the difference, their team up series will see them take on The Hand. This is a ninja organisation, with mystical origins, that is nevertheless involved in organised crime and can be presented, as it has been so far for Netflix, within the context of crime stories.

Marvel’s Chief Creative Officer Joe Quesada has defended The Defenders being The Defenders by pointing out that the original team are largely unknown outside comics fandom, and their name means nothing to the public at large. (Although they have, of course, heard of all three of its constituent members.) Of course, for some this might sensible provoke the question "Why use it then?" What is this series called The Defenders at all?

The (original) Defenders were seen as a "non-team", a phrase occasionally used in the pages of their appearances. There was something deconstructive about this kind of team up. It was the pairing of characters who were unsuited to working, even to appearing, together and who would really rather not. (They had, after all, been brought together in the first place simply because Roy Thomas happened to write their separate titles.) The stories told with the group in some ways challenged and confronted the cliches of the decades old form that had begun back in All-Star Comics #3.

The line-up, and tone, of Netflix’s Defenders more resembles that of another, deliberately slightly interrogative non-team, that of the short-lived Marvel Knights book of 2000-2001. This did share The Defenders somewhat abstract definition of "team", featuring characters who didn’t like each other and didn’t want to work together, albeit without any mystical element to how they were brought together. Marvel Knights was also, in theory, the flagship of the line of the same name, at the time edited by... Joe Quesada. Hmm.

In recent years, Marvel have frequently cheerfully remodelled their comics - the original medium for almost all their characters - in order to incorporate changes and innovations pioneered as part of their film and television projects. Remixing their characters and the way they are grouped together in response to the success of their screen empire. The Guardians of the Galaxy, for example, have become more prominent in the comics, while characters whose film rights lie with film companies other than Marvel’s own, such as the aforementioned Fantastic Four, have been pushed to the margins. Accordingly, this August sees the launch of a new The Defenders title, featuring the lineup of characters from the television series.

Some loyal comics readers see this a case of the tail wagging the dog. Others might like to take notice of the metaphor used by comics writer Grant Morrison in his 2011 book SuperGods: Our World In The Age Of The Superhero. There, Morrison argued that comic books, while the medium in which these characters were created, was essentially the discarded booster section of the rocket in which they had been fired into the public consciousness, reaching vastly greater audiences in the process. 

“That’s not The Defenders,” commented a friend of mine on seeing a publicity photograph for the series a few weeks ago. It is now, mate. It is now.