Science, God, and the ultimate evolutionary question

Until science proves the origin of the very first cells, many will wheel out God as the default expl

Until science proves the origin of the very first cells, many will wheel out God as the default explanation.

No-one who has visited Richard Dawkins' website recently would have failed to notice the prominence given to an award being offered of up to 2 million dollars. Unfortunately for most of us, nobody will be granted the funding unless they put together a proposal for scientific research into the origin of life on our planet.

It's hardly a surprise that the site should draw attention to the award. After all, however much we think that we know about evolution, science is far from providing a confident explanation of the origin of the very first cells from which all life evolved. Until this gap in scientific knowledge is filled, many believers will continue to resort to God as the default explanation. For some, it must have been God who planted the first living cells on the planet, before leaving the stage and letting evolution take over. For others, the fact that no-one can prove how life originated sounds the death knell for evolution itself but is music to the ears of those who believe in Adam and Eve.

But are they right? Is science incapable of explaining the emergence of the first cells from which all life originated without the need for God?

In 1953 biologist Stanley Miller set up an experiment in the lab, intended to recreate what scientists call the earth's "primordial soup" when life first appeared 3.5 billion years ago. He created a sealed environment comprising boiling water and electric probes to simulate the effect of lightening on some of the young planet's hot waters. Thrown into the mix were methane, ammonia and hydrogen, the gases believed to be present on the early earth. The aim was to see whether anything related to life would form. Within a week, five amino acids had appeared in the water. This was a stunning result. After all, amino acids are the molecules which join up to form proteins inside living cells.

But to create proteins - and therefore life - amino acids must be strung together in a very specific order. And cells require DNA to do this. But how could something as complex as DNA have come into existence? Miller's experiment didn't answer that.

A possible explanation was found after a meteorite, slightly older than earth, crashed down in Australia in 1969. Amazingly one of the DNA bases was found inside the rock. Since the early earth was bombarded by meteorites for millions of years, this raises the tantalising possibility that DNA and RNA could have arrived here on meteorites around the time that life first appeared on the planet. This provides a partial explanation of how the amino acids could have developed into life.

But there are problems with the idea that life began in a Miller-like primordial soup. Analysis of ancient rocks has made it plain that at the time that life appeared, the earth was no longer rich in methane, ammonia and hydrogen. Besides, any soup would have been thermodynamically flat. This means that there was probably nothing to force the various molecules to react with each other, whether or not extraterrestrial DNA and RNA molecules were also present. And so far, scientists haven't been able to explain how the necessary molecules would have come together without a cell membrane.

But there is a different theory which addresses all these concerns.

It is well-known that the continents have been drifting apart throughout the lifetime of the planet. This is due to the movement of tectonic plates below the oceans. As these plates strike each other, new rocks are exposed to the sea water. This creates alkaline hydrothermal vents. The water physically reacts with the rocks and this releases heat along with gases reminiscent of Miller's experiments. As a result, warm alkaline hydrothermal fluids percolate into the cold oceans and, near the vents, structures are created which look rather like stalagmites and which are riddled with tiny compartments. These compartments could have been ideal places for chemical compounds from the gases to concentrate and combine to form early life in a fairly enclosed environment.

Although the existence of these vents had been predicted decades ago, it wasn't until 2000 that one was discovered in a part of the Atlantic Ocean which has been named Lost City. Scientists have analysed the cell-sized pores in the structures which were found there and concluded that they were almost ideal reaction vessels for producing the first life. What's more, the chemical imbalance between the sea water and the gases could have created an electrical charge which in turn possibly caused the chemical reactions needed to kick-start the creation of life.

But as I mentioned earlier, it's not sufficient to work out how the first amino acids may have appeared. It's also necessary to explain how DNA could have come onto the scene. Unfortunately DNA can't evolve without proteins. And proteins can't evolve without DNA.

Many scientists believe that the answer lies in the RNA World Theory. In 2007 it was discovered that nucleotides (and so RNA) could grow in simulated vents. At around the same time a scientific paper was published which concluded that RNA may have developed by living inside mineral cells in the vents. Biochemist Nick Lane believes once that had happened, RNA may have changed to DNA virtually spontaneously.

And so the hydrothermal vents theory provides a plausible account of how the first life could have formed on earth along with the DNA which was necessary to replicate it. But the theory certainly has difficulties. In fact, a similar theory based on a different type of vents, black smokers, is now generally given short shrift by the scientific community. Perhaps the hydrothermal vents theory will likewise come unstuck.

This is a difficult area of science. No doubt whoever receives that award, will have to work hard to earn every cent.

Andrew Zak Williams has written for the Independent and the Humanist and is a contributor to Skeptic Magazine. His email address is: andrewbelief@gmail.com

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Brexit could destroy our NHS – and it would be the government's own fault

Without EU citizens, the health service will be short of 20,000 nurses in a decade.

Aneurin Bevan once said: "Illness is neither an indulgence for which people have to pay, nor an offence for which they should be penalised, but a misfortune, the cost of which should be shared by the community."

And so, in 1948, the National Health Service was established. But today, the service itself seems to be on life support and stumbling towards a final and fatal collapse.

It is no secret that for years the NHS has been neglected and underfunded by the government. But Brexit is doing the NHS no favours either.

In addition to the promise of £350m to our NHS every week, Brexit campaigners shamefully portrayed immigrants, in many ways, as as a burden. This is quite simply not the case, as statistics have shown how Britain has benefited quite significantly from mass EU migration. The NHS, again, profited from large swathes of European recruitment.

We are already suffering an overwhelming downturn in staffing applications from EU/EAA countries due to the uncertainty that Brexit is already causing. If the migration of nurses from EEA countries stopped completely, the Department of Health predicts the UK would have a shortage of 20,000 nurses by 2025/26. Some hospitals have significantly larger numbers of EU workers than others, such as Royal Brompton in London, where one in five workers is from the EU/EAA. How will this be accounted for? 

Britain’s solid pharmaceutical industry – which plays an integral part in the NHS and our everyday lives – is also at risk from Brexit.

London is the current home of the highly prized EU regulatory body, the European Medicine Agency, which was won by John Major in 1994 after the ratification of the Maastricht Treaty.

The EMA is tasked with ensuring that all medicines available on the EU market are safe, effective and of high quality. The UK’s relationship with the EMA is unquestionably vital to the functioning of the NHS.

As well as delivering 900 highly skilled jobs of its own, the EMA is associated with 1,299 QPPV’s (qualified person for pharmacovigilance). Various subcontractors, research organisations and drug companies have settled in London to be close to the regulatory process.

The government may not be able to prevent the removal of the EMA, but it is entirely in its power to retain EU medical staff. 

Yet Theresa May has failed to reassure EU citizens, with her offer to them falling short of continuation of rights. Is it any wonder that 47 per cent of highly skilled workers from the EU are considering leaving the UK in the next five years?

During the election, May failed to declare how she plans to increase the number of future homegrown nurses or how she will protect our current brilliant crop of European nurses – amounting to around 30,000 roles.

A compromise in the form of an EFTA arrangement would lessen the damage Brexit is going to cause to every single facet of our NHS. Yet the government's rhetoric going into the election was "no deal is better than a bad deal". 

Whatever is negotiated with the EU over the coming years, the NHS faces an uncertain and perilous future. The government needs to act now, before the larger inevitable disruptions of Brexit kick in, if it is to restore stability and efficiency to the health service.

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