Close on the heels of Santander UK chief executive António Horta-Osório quitting the bank to join Lloyds, the former has been hit by another blow as its finance director Antonio Lorenzo and chief risk officer Juan Colombas are also stepping down.
Colombás will join Lloyds in January as chief risk officer while Lorenzo will join the high street bank in March as director of its wealth and international division.
Santander has lost three key board directors within a month after Horta-Osorio left as head of the bank's UK operations this month to become CEO of Lloyds replacing Eric Daniels on March 1.
The Spanish bank has gone ahead to appoint Monica Cueva as its new financial controller, while Jose María Nus will be the new head of risk, and Justo Gómez, the new finance director.
Earlier, Ana Patricia Botín took over the running of Santander UK from Horta-Osório after receiving approval from the Financial Services Authority.
Meanwhile, speculation was rife that Santander will have to abandon plans for the flotation of its British business, which would have raised more than £3bn in the wake of departure of its top bankers.