Show Hide image

Queen Victoria on cannabis, and all the other things you never knew about drugs

Modern governments have long demonised drugs, but the world now may be inching its way back towards the more rational view held in the 19th century.

A London opium den in the 1870s, by Gustav Doré
Image: Hulton Archive/Getty

Drugged: the Science and Culture Behind Psychotropic Drugs
Richard J Miller
Oxford University Press, 384pp, £25.99

People who study drugs and human society can arrive at curious historical theories. Early in this book we learn of the idea that “the name Jesus actually meant something along the lines of ‘semen’ and that Christ meant something like ‘giant erect mushroom penis’”. It would be invidious, perhaps, to suggest that such symbolic interpretations occur only to researchers who are completely off their tits.

Happily, Richard J Miller, an eminent professor of pharmacology, soon leaves such psychedelic conspiracy theories behind for a fascinating and illuminating survey of all the major “psychotropic” drugs – defined as “chemical substances that enter the brain and change the way it operates” – from mushrooms and opiates, cocaine, LSD and MDMA, to Big Pharma’s arsenal of tranquillisers, antipsychotics and antidepressants, and thence to alcohol, nicotine, tea, and coffee. (“Caffeine is the most widely consumed psychoactive drug in the world.”)

Miller deploys numerous chemical diagrams and occasional dense technical explanations of molecular activity, but also cites Thomas De Quincey and 20th-century literary psychonauts such as Ken Kesey. The reports of self-experimenting scientists constitute their own kind of wan poetry. “[Albert] Hofmann originally reported that ergine and isoergine” – which he had isolated from seeds of the morning glory plant – “were only weakly hallucinogenic at best, although they did give him a feeling of ‘unreality’ and made him feel ‘life was completely meaningless’”.

Modern governments have long demonised drugs, repeatedly commissioning expert reports and then denouncing their findings; or whipping up drug scares for frankly racist purposes, as with the American campaign in the Great Depression against the drug of choice for Mexican labourers, cannabis. (The head of the Federal Bureau of Narcotics was the first to popularise the name “marijuana” in English, precisely because it sounded foreign.) The 19th century had been a more rational age, as well as a more innocent one. In that era, Miller explains, “The medicinal uses of cannabis were taken very seriously and endorsed by authorities such as the Lancet […] Even Queen Victoria was prescribed tincture of cannabis. It is believed she was amused (perhaps very amused).” The world now may be inching its way back to a more sensible view, given the legalisation of cannabis by Uruguay in December, and the growing movement for decriminalisation in many American states.

Against the hostility to evidence of modern legislators, Miller is careful to emphasise, humanely, that illegal drugs as well as legal ones have “highly desirable” effects, not just undesirable ones such as addictiveness, or death in the wrong dose or cocktail. (It was reported that the heroin found in the late actor Philip Seymour Hoffman’s hotel room was part of a batch mixed with the super-potent painkiller fentanyl.) After all, if drugs did not have desirable effects, people would never have got into the habit of taking them. “If we consider some of the beneficial medical effects of alcohol,” Miller writes – an unusual way to begin a sentence in our puritanical, units-counting day – “these would include anticonvulsant, sedative, and hypnotic effects.” Nicotine and caffeine, meanwhile, are good for cognition. And opium, Miller points out, is “the most effective drug ever discovered for combating the most basic of all human complaints: pain. Whatever advances are made in medicine, nothing could really be more important than that.”

He goes so far as to argue that “morphine is the most significant chemical substance mankind has ever encountered”. (It is only disappointing that here Miller uses the phrase “chemical substance” in the popular but illogical sense that somehow excludes air, water, and food.) He is fondly non-judgemental, too, on the splendid variety of Victorian pick-me-ups that blossomed before modern prohibition. One, a tonic called Vin Mariani, “was a concoction of cocaine in claret, which was certainly a very reasonable idea”.

It is also useful to have an author on this subject who can remember the 1960s, even though he was there. In a charming aside, Miller explains: “One should remember that at that time, everybody was very infatuated with hallucinogenic drugs and the society they represented. We were all revolutionaries. We thought revolutionary thoughts, listened to Jefferson Airplane, and ingested psychedelic drugs.” But this wasn’t just about tuning in and dropping out: the drug culture was hugely important, as Miller shows, to the emerging field of psychopharmacology, as studying the effects of mescaline or LSD led psychiatrists to suggest new paths of research for the treatment of schizophrenia and other disorders.

Perhaps the most interesting facet of the book is Miller’s demonstration that the progress of understanding in this field has been very far from the smoothly efficient hypothesis-driven caricature of science that is often promoted by its own defenders. For a start, most of the important therapeutic drugs of the 20th century were discovered by accident, and some in surprising places. Antipsychotics were developed from substances produced during the search for fashionable clothes dyes in the 19th century; while antidepressants came out of research that sought novel compounds deriving from a glut of leftover rocket fuel from the Nazis’ V2 programme.

Only after the beneficial effects of such substances were serendipitously noticed by scientists did they then try to figure out why they worked. Miller’s explanations of these investigations make for excellent intellectual detective stories, as much for naturally produced drugs as synthetic ones. Why should the human brain, for example, have “receptors” that spark hungrily in the presence of nicotine or opiates? It was not, as it turned out, that God intended us to smoke our heads off, but that these vegetable substances mimicked what were subsequently discovered to be the brain’s own signalling chemicals – neurotransmitters. (Miller doesn’t address the further interesting question as to why the poppy or tobacco plant should produce substances that trick our receptors in the first place. Happy accident – or brilliant evolutionary strategy for getting themselves widely cultivated?) Thus, research on drugs has contributed enormously to our understanding of the brain.

That understanding is, of course, still in its infancy, and another salutary scientific message of Miller’s book is its emphasis on how much we still don’t know. He offers a useful corrective to simplistic pop-science stories about the allegedly singular roles of dopamine (the so-called reward chemical) or serotonin (“happiness”) in the brain: these are families of chemicals, he shows, with a wide variety of functions. Writing early on about hallucinogens, he comments: “A complete understanding of the way [they] produce their effects would entail a comparable understanding of the neurobiology of consciousness, something that we don’t really possess.” (That “really” is a severe understatement.)

Meanwhile, it is still not clear how medicines prescribed to millions work, when they do at all – “there are some odd things about the use of the available antidepressant drugs which nobody really understands” – and research on others (eg antipsychotics) has been stalled for decades. But Miller cites recent studies suggesting that targeting the brain’s inflammatory response might be a fruitful direction for future research, and we have certainly not exhausted the repertoire of potentially therapeutic substances to be found in plants. One might even add that the global internet-based market for synthetic “designer drugs”, in which enterprising chemists keep one step ahead of legal bans by rearranging atoms in unforeseen combinations – in passing, Miller characterises this stylishly as a “hypertext drug phenomenon” – could also throw up a molecule that might one day help millions. It’s no more far-fetched, at least, than the idea that licking a toad could give you an enormous sense of well-being.

Steven Poole’s “Who Touched Base in My Thought Shower? A Treasury of Unbearable Office Jargon” is published by Sceptre (£9.99)

 

Jeremy Corbyn. Photo: Getty
Show Hide image

Lexit: the EU is a neoliberal project, so let's do something different when we leave it

Brexit affords the British left a historic opportunity for a decisive break with EU market liberalism.

The Brexit vote to leave the European Union has many parents, but "Lexit" – the argument for exiting the EU from the left – remains an orphan. A third of Labour voters backed Leave, but they did so without any significant leadership from the Labour Party. Left-of-centre votes proved decisive in determining the outcome of a referendum that was otherwise framed, shaped, and presented almost exclusively by the right. A proper left discussion of the issues has been, if not entirely absent, then decidedly marginal – part of a more general malaise when it comes to developing left alternatives that has begun to be corrected only recently, under Jeremy Corbyn and John McDonnell.

Ceding Brexit to the right was very nearly the most serious strategic mistake by the British left since the ‘70s. Under successive leaders Labour became so incorporated into the ideology of Europeanism as to preclude any clear-eyed critical analysis of the actually existing EU as a regulatory and trade regime pursuing deep economic integration. The same political journey that carried Labour into its technocratic embrace of the EU also resulted in the abandonment of any form of distinctive economics separate from the orthodoxies of market liberalism.

It’s been astounding to witness so many left-wingers, in meltdown over Brexit, resort to parroting liberal economics. Thus we hear that factor mobility isn’t about labour arbitrage, that public services aren’t under pressure, that we must prioritise foreign direct investment and trade. It’s little wonder Labour became so detached from its base. Such claims do not match the lived experience of ordinary people in regions of the country devastated by deindustrialisation and disinvestment.

Nor should concerns about wage stagnation and bargaining power be met with finger-wagging accusations of racism, as if the manner in which capitalism pits workers against each other hasn’t long been understood. Instead, we should be offering real solutions – including a willingness to rethink capital mobility and trade. This places us in direct conflict with the constitutionalised neoliberalism of the EU.

Only the political savvy of the leadership has enabled Labour to recover from its disastrous positioning post-referendum. Incredibly, what seemed an unbeatable electoral bloc around Theresa May has been deftly prized apart in the course of an extraordinary General Election campaign. To consolidate the political project they have initiated, Corbyn and McDonnell must now follow through with a truly radical economic programme. The place to look for inspiration is precisely the range of instruments and policy options discouraged or outright forbidden by the EU.

A neoliberal project

The fact that right-wing arguments for Leave predominated during the referendum says far more about today’s left than it does about the European Union. There has been a great deal of myth-making concerning the latter –much of it funded, directly or indirectly, by the EU itself.

From its inception, the EU has been a top-down project driven by political and administrative elites, "a protected sphere", in the judgment of the late Peter Mair, "in which policy-making can evade the constraints imposed by representative democracy". To complain about the EU’s "democratic deficit" is to have misunderstood its purpose. The main thrust of European economic policy has been to extend and deepen the market through liberalisation, privatisation, and flexiblisation, subordinating employment and social protection to goals of low inflation, debt reduction, and increased competitiveness.

Prospects for Keynesian reflationary policies, or even for pan-European economic planning – never great – soon gave way to more Hayekian conceptions. Hayek’s original insight, in The Economic Conditions of Interstate Federalism, was that free movement of capital, goods, and labour – a "single market" – among a federation of nations would severely and necessarily restrict the economic policy space available to individual members. Pro-European socialists, whose aim had been to acquire new supranational options for the regulation of capital, found themselves surrendering the tools they already possessed at home. The national road to socialism, or even to social democracy, was closed.

The direction of travel has been singular and unrelenting. To take one example, workers’ rights – a supposed EU strength – are steadily being eroded, as can be seen in landmark judgments by the European Court of Justice (ECJ) in the Viking and Laval cases, among others. In both instances, workers attempting to strike in protest at plans to replace workers from one EU country with lower-wage workers from another, were told their right to strike could not infringe upon the "four freedoms" – free movement of capital, labour, goods, and services – established by the treaties.

More broadly, on trade, financial regulation, state aid, government purchasing, public service delivery, and more, any attempt to create a different kind of economy from inside the EU has largely been forestalled by competition policy or single market regulation.

A new political economy

Given that the UK will soon be escaping the EU, what opportunities might this afford? Three policy directions immediately stand out: public ownership, industrial strategy, and procurement. In each case, EU regulation previously stood in the way of promising left strategies. In each case, the political and economic returns from bold departures from neoliberal orthodoxy after Brexit could be substantial.

While not banned outright by EU law, public ownership is severely discouraged and disadvantaged by it. ECJ interpretation of Article 106 of the Treaty on the Functioning of the European Union (TFEU) has steadily eroded public ownership options. "The ECJ", argues law professor Danny Nicol, "appears to have constructed a one-way street in favour of private-sector provision: nationalised services are prima facie suspect and must be analysed for their necessity". Sure enough, the EU has been a significant driver of privatisation, functioning like a ratchet. It’s much easier for a member state to pursue the liberalisation of sectors than to secure their (re)nationalisation. Article 59 (TFEU) specifically allows the European Council and Parliament to liberalise services. Since the ‘80s, there have been single market programmes in energy, transport, postal services, telecommunications, education, and health.

Britain has long been an extreme outlier on privatisation, responsible for 40 per cent of the total assets privatised across the OECD between 1980 and 1996. Today, however, increasing inequality, poverty, environmental degradation and the general sense of an impoverished public sphere are leading to growing calls for renewed public ownership (albeit in new, more democratic forms). Soon to be free of EU constraints, it’s time to explore an expanded and fundamentally reimagined UK public sector.

Next, Britain’s industrial production has been virtually flat since the late 1990s, with a yawning trade deficit in industrial goods. Any serious industrial strategy to address the structural weaknesses of UK manufacturing will rely on "state aid" – the nurturing of a next generation of companies through grants, interest and tax relief, guarantees, government holdings, and the provision of goods and services on a preferential basis.

Article 107 TFEU allows for state aid only if it is compatible with the internal market and does not distort competition, laying out the specific circumstances in which it could be lawful. Whether or not state aid meets these criteria is at the sole discretion of the Commission – and courts in member states are obligated to enforce the commission’s decisions. The Commission has adopted an approach that considers, among other things, the existence of market failure, the effectiveness of other options, and the impact on the market and competition, thereby allowing state aid only in exceptional circumstances.

For many parts of the UK, the challenges of industrial decline remain starkly present – entire communities are thrown on the scrap heap, with all the associated capital and carbon costs and wasted lives. It’s high time the left returned to the possibilities inherent in a proactive industrial strategy. A true community-sustaining industrial strategy would consist of the deliberate direction of capital to sectors, localities, and regions, so as to balance out market trends and prevent communities from falling into decay, while also ensuring the investment in research and development necessary to maintain a highly productive economy. Policy, in this vision, would function to re-deploy infrastructure, production facilities, and workers left unemployed because of a shutdown or increased automation.

In some cases, this might mean assistance to workers or localities to buy up facilities and keep them running under worker or community ownership. In other cases it might involve re-training workers for new skills and re-fitting facilities. A regional approach might help launch new enterprises that would eventually be spun off as worker or local community-owned firms, supporting the development of strong and vibrant network economies, perhaps on the basis of a Green New Deal. All of this will be possible post-Brexit, under a Corbyn government.

Lastly, there is procurement. Under EU law, explicitly linking public procurement to local entities or social needs is difficult. The ECJ has ruled that, even if there is no specific legislation, procurement activity must "comply with the fundamental rules of the Treaty, in particular the principle of non-discrimination on grounds of nationality". This means that all procurement contracts must be open to all bidders across the EU, and public authorities must advertise contracts widely in other EU countries. In 2004, the European Parliament and Council issued two directives establishing the criteria governing such contracts: "lowest price only" and "most economically advantageous tender".

Unleashed from EU constraints, there are major opportunities for targeting large-scale public procurement to rebuild and transform communities, cities, and regions. The vision behind the celebrated Preston Model of community wealth building – inspired by the work of our own organisation, The Democracy Collaborative, in Cleveland, Ohio – leverages public procurement and the stabilising power of place-based anchor institutions (governments, hospitals, universities) to support rooted, participatory, democratic local economies built around multipliers. In this way, public funds can be made to do "double duty"; anchoring jobs and building community wealth, reversing long-term economic decline. This suggests the viability of a very different economic approach and potential for a winning political coalition, building support for a new socialist economics from the ground up.

With the prospect of a Corbyn government now tantalisingly close, it’s imperative that Labour reconciles its policy objectives in the Brexit negotiations with its plans for a radical economic transformation and redistribution of power and wealth. Only by pursuing strategies capable of re-establishing broad control over the national economy can Labour hope to manage the coming period of pain and dislocation following Brexit. Based on new institutions and approaches and the centrality of ownership and control, democracy, and participation, we should be busy assembling the tools and strategies that will allow departure from the EU to open up new political-economic horizons in Britain and bring about the profound transformation the country so desperately wants and needs.

Joe Guinan is executive director of the Next System Project at The Democracy Collaborative. Thomas M. Hanna is research director at The Democracy Collaborative.

This is an extract from a longer essay which appears in the inaugural edition of the IPPR Progressive Review.