Registered user login:

Toll of toxic trailers

Anthony Lane

Published 13 March 2008

Two and a half years after Hurricane Katrina 114,000 people are still living in cramped trailers - now it seems many have been exposed to a cancer-causing chemical

Two and a half years after Hurricane Katrina, 38,000 families, or approximately 114,000 people, have yet to receive the compensation promised by the federal government and are still living in cramped trailers provided by the Federal Emergency Management Agency (Fema).

But just when it seemed that post-Katrina New Orleans could not bear witness to greater suffering or government incompetence, Fema made a stunning announcement. Families living in many of these trailers have been exposed to toxic levels of a cancer-causing chemical.

Formaldehyde is an industrial chemical that also occurs naturally. It is often found in materials used by the construction industry, with the effect that minute quantities, on average 16 parts per billion (ppb), are found in most homes. Indeed, the US Environmental Protection Agency allows no more than that proportion in the air of new buildings constructed for its own use. However, recent tests of 519 randomly selected trailers, carried out by the Centres for Disease Control and Prevention (CDC), found that some had levels as high as 590ppb. The study stated that such a concentration would make 5 per cent of adults sick and would cause breathing difficulties for a third of children and elderly people.

The federal government has yet to investigate how this could have occurred. One theory is that after Katrina manufacturers of trailers were faced with such large orders - 144,000 families ended up in mobile homes - that they ran out of low-emission materials.

Incredibly, internal documents show that Fema was aware of the difficulty as long ago as March 2006, when reports began coming in of severe health problems. Yet Fema did not run any tests. Emails from its legal department advised that testing for the toxin "would imply Fema ownership of the issue" and that the agency would have no option but to act. Another email read: "Should [tests] indicate some problem, the clock is running on our duty to respond to them."

In the past two years, trailer occupants have complained of rashes, headaches, asthma, nosebleeds and sore throats. A few have mouth tumours. There are even suggestions that the toxic trailers have killed. A child living in one in Texas died in August 2006. The Fema agent investigating reported that her nose began to burn after her short visit to the trailer. That same year, in St Tammany, Louisiana, a man who had complained about formaldehyde fumes was found dead in his trailer.

Louisiana's Republican governor, Bobby Jindal, has called Fema's inaction "simply inexcusable", while the state's Democratic senator, Mary Landrieu, has accused the government of "gross incompetence".

Visiting last August, I noted surprising numbers of people coughing despite the summer heat. At the time, I presumed this was due to Louisiana having the second-worst health-care indicators in the entire country. But July temperatures can reach as high as 40°C; it is thought that as trailers bake, the concentration of the chemical increases greatly. So the CDC tests, carried out this winter, probably understated the scale of toxin exposure.

Fema is now acting urgently to move people out of the trailers before the summer, and all the elderly within two weeks.

This will not be easy, as New Orleans is desperately short of housing. Rents are 40 per cent higher than before Katrina, which destroyed 41,000 lower-income apartments. The city's mayor, Ray Nagin, fears that trailer occupants will now be forced out of the city once again, and warned of a "second great displacement" in an open letter to President Bush. Then there are the city's 12,000 homeless, many in a makeshift colony below an overpass less than a mile from the city centre.

Even if the mass evacuation is achieved, there are huge health implications, especially for small children whose immune systems have been weakened by two years in these trailers. A pregnant mother who had her trailer tested after her little girl kept falling ill found the level of formaldehyde to be 2,400ppb. The CDC has announced that children who lived in Fema trailers will now be the subjects of a long-term study. In his letter to the president, Mayor Nagin demanded "guaranteed access to state-of-the-art medical care for any future formaldehyde-related medical conditions".

Mass actions representing tens of thousands of trailer occupants are now being launched against trailer manufacturers. Lawyers representing trailer residents say that Fema itself is likely to become a defendant in the near future.

Donald Powell, Bush's federal co-ordinator for rebuilding the Gulf Coast, resigned last month, voicing hope that his time in office had helped to restore in Katrina victims at least a "fragile" trust in the federal government.

Yet the reality for many victims of Hurricane Katrina is that, denied compensation for the destruction of their homes and threatened with eviction from New Orleans for a second time, many must struggle to hold the government accountable for the destruction of their health.

Post this article to

  • Digg
  • del.icio.us
  • newsvine
  • Reddit

1 comment from readers

rmforall
15 March 2008 at 01:35

methanol impurity in alcohol drinks [ and aspartame ] is turned into

neurotoxic formic acid, prevented by folic acid, re Fetal Alcohol Syndrome,

BM Kapur, DC Lehotay, PL Carlen at U. Toronto, Alc Clin Exp Res 2007 Dec.

plain text: detailed biochemistry, CL Nie et al. 2007.07.18: Rich Murray

2008.02.24

http://rmforall.blogspot.com/2008_02_01_archive.htm

Sunday, February 24, 2008

http://groups.yahoo.com/group/aspartameNM/message/1524

____________________________________________________

[ Rich Murray comments: As a medical layman volunteer information

activist for aspartame and related toxicity issues since January 1999,

I note with appreciation the remarkable exponential progress on all

fronts, including a rapidly emerging consensus about the primary

importance of all toxicity challenges for our world.

This lengthy review features in detail two quite different, revolutionary

contributions, from Canada, and England and China.

It is indicative of our times that the CL Nie et al. study, 2007

appears in a free, open access journal-- indeed,

as all life and death information must.

Following rather vigorously, indeed blindly, the imperatives of

single-minded, profit-driven capitalist competition -- manipulating

adroitly research, education, media, citizens, governments -- many

great global corporations have inevitably created results that

oppose the common good. Alcohol and tobacco are well known.

Realistically, any further manipulations can only lead to inevitable

and even sudden corporate meltdowns, in the context of an

unfettered, cooperative, democratic global information forum,

the Internet.

Now, it is as easy and cheap to compose and instantly post a

30-page review as 3 pages a decade ago -- and such reviews

are archived forever in multiple collections, open via global search

engines to a billion Net citizens.

Perforce, and increasingly happily, all societal entities will have to

operate by high and shared voluntary universal standards

for the common good. ]

http://www.blackwell-synergy.com/doi/abs/10.1111/j.1530-0277...

Alcoholism: Clinical and Experimental Research

Volume 31 Issue 12 Page 2114-2120, December 2007

Bhushan M. Kapur, b.kapur@utoronto.ca;

Arthur C. Vandenbroucke, PhD, FCACB

Yana Adamchik,

Denis C. Lehotay, dlehotay@health.gov.sk.ca;

Peter L. Carlen carlen@uhnres.utoronto.ca;

(2007) Formic Acid, a Novel Metabolite of Chronic Ethanol

Abuse, Causes Neurotoxicity, Which Is Prevented by Folic Acid

Alcoholism: Clinical and Experimental Research 31 (12), 2114-2120.

doi:10.1111/j.1530-0277.2007.00541.x

Abstract

Background:

Methanol is endogenously formed in the brain and is present as a

congener in most alcoholic beverages.

Because ethanol is preferentially metabolized over methanol (MeOH)

by alcohol dehydrogenase, it is not surprising that MeOH

accumulates in the alcohol-abusing population.

This suggests that the alcohol-drinking population will have higher

levels of MeOH's neurotoxic metabolite, formic acid (FA).

FA elimination is mediated by folic acid.

Neurotoxicity is a common result of chronic alcoholism.

This study shows for the first time that FA,

found in chronic alcoholics, is neurotoxic

and this toxicity can be mitigated by folic acid administration.

Objective:

To determine if FA levels are higher in the alcohol-drinking

population and to assess its neurotoxicity in organotypic

hippocampal rat brain slice cultures.

Methods:

Serum and CSF FA was measured in samples from both ethanol

abusing and control patients, who presented to a hospital emergency

department. [ CSF = Cerebral Spinal Fluid ]

FA's neurotoxicity and its reversibility by folic acid were assessed

using organotypic rat brain hippocampal slice cultures using clinically

relevant concentrations.

Results:

Serum FA levels in the alcoholics

(mean ± SE: 0.416 +- 0.093 mmol/l, n = 23)

were significantly higher than in controls

(mean ± SE: 0.154 +- 0.009 mmol/l, n = 82) (p < 0.0002).

FA was not detected in the controls' CSF (n = 20),

whereas it was >0.15 mmol/l in CSF of 3 of the 4 alcoholic cases.

Low doses of FA from 1 to 5 mmol/l added for 24, 48 or 72 hours

to the rat brain slice cultures caused neuronal death as measured by

propidium iodide staining.

When folic acid (1 umol/l) was added with the FA,

neuronal death was prevented. [ umol = micromole ]

Conclusions:

Formic acid may be a significant factor in the neurotoxicity of

ethanol abuse.

This neurotoxicity can be mitigated by folic acid administration

at a clinically relevant dose.

Key Words:

Formic Acid, Folic Acid, Methanol, Neurotoxicity, Alcoholism.

From the Department of Clinical Pathology (BMK),

Sunnybrook Health Science Centre,

Division of Clinical Pharmacology and Toxicology,

The Hospital for Sick Children, Toronto, Ontario, Canada;

St. Michael's Hospital (ACV), Toronto, Canada;

Department of Laboratory Medicine and Pathobiology

(BMK, ACV), Faculty of Medicine,

University of Toronto, Toronto, Ontario, Canada;

Departments of

Medicine (Neurology) and Physiology (YA, PLC),

Toronto Western Research Institute,

University of Toronto, Toronto, Ontario, Canada;

and University of Saskatchewan (DLC), Saskatchewan, Canada.

Received for publication May 1, 2007;

accepted September 24, 2007.

Reprint requests: Dr. Bhushan M. Kapur,

Department of Clinical Pathology,

Sunnybrook Health Science Centre,

2075 Bayview Ave, Toronto, Ontario, M4N 3M5, Canada;

Fax: 416-813-7562; E-mail: b.kapur@utoronto.ca;

Copyright 2007 by the Research Society on Alcoholism.

DOI: 10.1111/j.1530-0277.2007.00541.x

Alcoholism: Clinical and Experimental Research 2007 Dec.

Alcohol Clin Exp Res, Vol. 31, No 12, 2007: pp 2114-2120

NEUROTOXICITY AND BRAIN damage are common

concomitants findings of chronic alcoholism

(Carlen and Wilkinson, 1987; Carlen et al., 1981; Harper,

2007).

The cause of ethanol-induced neurotoxicity is still unclear.

We present here a novel hypothesis for neurotoxicity:

increased formic acid (FA) levels produced from methanol

(MeOH), whose catabolism is blocked by ethanol.

Axelrod and Daly (1965) demonstrated the endogenous formation

of MeOH from S-adenosylmethionine (SAM) in the pituitary

glands of humans and various other mammalian species.

Presence of MeOH in the breath of human subjects was

reported by Ericksen and Kulkarni (1963).

Most alcoholic beverages also have a small amount of MeOH

as a congener (Sprung et al., 1988).

As ethanol (EtOH) has a higher affinity for

alcohol dehydrogenase (ADH) than MeOH,

EtOH is preferentially metabolized (Mani et al., 1970).

As a result, MeOH accumulation from endogenously produced

MeOH, and/or, that consumed as part of an alcoholic beverage,

has been reported in concentrations up to 2 mmol/l in heavy

drinkers (Majchrowicz and Mendelson, 1971).

Toxicity resulting from MeOH consumption is extensively

documented in both humans and animals and has been

attributed to its metabolite, FA (Benton and Calhoun, 1952;

Roe, 1946, 1955; Wood, 1912; Wood and Buller, 1904).

The rate of formate oxidation and elimination is dependent on

adequate levels of hepatic folic acid, particularly hepatic

tetrahydrofolate (THF)

(Johlin et al., 1987; Tephly and McMartin, 1974).

Significantly higher formate levels were obtained when

folate-deficient animals were exposed to MeOH as compared

with folate-sufficient animals (Lee et al., 1994;

McMartin et al., 1975; Noker et al., 1980).

To understand ethanol's toxicity, one must consider FA

produced from MeOH, and its elimination mediated by folic acid.

We postulate that in the chronically drinking patient,

we will find higher levels of FA than in the nondrinking population,

and that formate is neurotoxic.

We also hypothesize that treatment with folic acid, which is a

critical factor in the catabolism of FA, can prevent or

diminish FA neurotoxicity.

Post your comment

Please note: you will need to login or register before your comment is displayed on the website

We want to encourage people to comment on our content and to exchange views with other readers and hope this will be done on a courteous basis. However, if you encounter posts which are offensive please let us know by emailing comments@newstatesman.co.uk and we will take swift action where necessary.

Read More

Vote!

Is capitalism finished?